CXCR7 is expressed in mature B cells and is involved in the regulation of their development and differentiation , specifically it is highly restricted to marginal zone B cells and its deletion or CXCR7 specific inhibition, reduces marginal zone B cell numbers and disrupts splenic marginal zone architecture . CpG-activated pDCs downregulate ...

2018年6月21日 · CXCR7, later renamed ACKR3, is a non-classical seven transmembrane-spanning receptor whose function as a signaling or non-signaling scavenger/decoy receptor is currently under debate. Even for cell signaling mechanisms, there has been inconsistency on whether CXCR7 couples to G-proteins or β-arrestins. Several reasons may contribute to this ...

2023年2月9日 · CXCR7 is frequently upregulated in aggressive cancers, including therapy-resistant neuroendocrine prostate cancer, partially due to the loss of AR and/or HIC1, an oncosupressor, concomitantly with ...

Although CXCR7 encodes two exons, only the last exon is the solely translated coding region (Broberg et al., 2002). Originally CXCR7 was considered as a receptor for calcitonin gene-related peptide (CGRP1) and vasoactive intestinal peptide (VIP) but studies have not been able to prove this (Cook et al., 1992; McLatchie et al., 1998).

2021年4月15日 · CXCR4/CXCR7 antagonism should prevent the development of metastases by interfering with tumor cell growth, migration and chemotaxis and favoring the frequency of T cells in TME. Herein, we discuss the current understanding on the role of CXCL12/CXCR4/CXCR7 cross-talk in tumor progression and immune cells recruitment providing support for a ...

2023年6月26日 · Importantly, the interactions of chemokine members CXCL12 and its receptors CXCR4 and CXCR7 have a broad impact on tumor cell proliferation, survival, angiogenesis, metastasis, and tumor microenvironment, and thus participate in the onset and development of many cancers including leukemia, breast cancer, lung cancer, prostate cancer and ...

CXCR7 is a recently deorphanized receptor for SDF-1 and I-TAC that is highly expressed at the protein level on the surface of malignant cells as compared to cells in normal adult tissues. CXCR7 binds SDF-1 with high affinity and exerts various biological effects depending on cell type as a result of initiation of signal transduction or its role as a scavenger-type receptor.

2025年2月27日 · Among the ligand-receptor pairs identified, MIF and its receptor ACKR3 (also known as CXCR7) demonstrated the highest probability (Figure 2A). This route of communication was especially strong between tumor cells and FIPs (Figure 2A; Table S4) and further enhanced in the terminal phase of cachexia (Figure 2B).

2020年11月23日 · CXCR7 may be neither a simple scavenger nor auxiliary receptor but plays an essential role in cell migration through cooperation with CXCR4. Some chemokine receptors referred to as atypical chemokine receptors (ACKRs) are thought to non-signaling decoys because of their inability to activate typical G-protein signaling pathways. CXCR7, also ...

2023年6月22日 · CXCR7 is upregulated in neuroendocrine PCa. We have previously reported that CXCR7 is a direct target of AR-mediated transcriptional repression and, as such, it is upregulated following enzalutamide treatment.To determine whether CXCR7 expression further increases as enzalutamide resistant PCa progresses to NEPC with a gain of neuroendocrine …