常见的参与药物代谢的酶中，占比最大的是 CYP酶，它主导药物的Ⅰ相代谢过程。 UGT酶（尿苷二磷酸葡萄糖醛酸转移酶） 占比第二，是人体Ⅱ相代谢中最重要的酶之一，参与着很多药物的代谢清除过程。

Cytochrome P450 (P450) and uridine 5'-diphosphate (UDP)-glucuronosyltransferase (UGT) catalyze oxidation and glucuronidation in drug metabolism, respectively. It is believed that P450 and UGT work separately because they perform distinct reactions and exhibit opposite membrane topologies on the endo …

2005年1月1日 · This chapter focuses on CYP enzymes for Phase I metabolism and UDP-glucuronosyltransferase (UGT) enzymes for Phase II metabolism. Understanding the involvement of P450 enzymes in drug metabolism is critical to assessing the potential for drug interaction with concomitant drugs, food, and endogenous substances.

Members of the cytochrome P450 (CYP450) and UDP-glycosyltransferase (UGT) gene superfamily have been shown to play essential roles in regulating secondary metabolite biosynthesis. However, the systematic identification of CYP450s and UGTs has not been reported in Aralia elata (Miq.) Seem, a highly valued medicinal plant.

Two drug‐metabolizing enzymes, cytochrome P450 (CYP) and UDP‐glucuronosyltransferase (UGT) form complexes. UGT2B7 interacts with and suppresses CYP3A4 activity by inhibiting substrate binding.

2023年10月27日 · In summary, the expression patterns of CYP and UGT enzymes in the brain exhibit both similarities and differences across species. The CYP1A, 1B, 2D, and 2E and UGT1A6 enzymes are present in multiple species, but CYP2D …

2017年7月1日 · UDP-glucuronosyltransferases (UGTs) are the primary phase II enzymes catalyzing the conjugation of glucuronic acid to the xenobiotics with polar groups for facilitating their clearance. The UGTs belong to a superfamily that consists of diverse isoforms possessing distinct but overlapping metabolic activity.

Examples of CYP- and UGT-mediated drug metabolism within the brain are presented at the end, illustrating the pivotal role of these enzymes in drug therapy and potential toxicity. In conclusion, this review enhances our understanding of drug metabolism's significance in the brain, with a specific focus on CYPs and UGTs.

地塞米松治疗可诱导不同程度的肝脏 CYP3As 和 UGT1As。 通过这种处理，CYP3A 的营业额提高了约两倍。 结论和启示 动力学参数的变化表明UGT1A9抑制CYP3A4活性的机制与UGT2B7几乎相同。 UGT 的管腔结构域包含抑制性相互作用位

2015年2月1日 · UDP-glucuronosyltransferase (UGT) and esterases are recognized as the most important non-P450 enzymes because of their high contribution to drug metabolism. UGTs catalyze the transfer of glucuronic acid to hydroxyl, carboxyl, or amine groups of compounds, whereas esterases hydrolyze compounds that contain ester, amide, and thioester bonds.