Cytochrome P450 17A1 (steroid 17α-monooxygenase, 17α-hydroxylase, 17-alpha-hydroxylase, 17,20-lyase, 17,20-desmolase) is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10. [5] .

1．酶特征：cyp17是一种 微粒体酶 ，具有两种功能：①孕烯醇酮和孕酮的17-羟化（17α-羟化酶活性）；②催化17-羟孕酮转化为雄烯二酮和17-羟孕烯醇酮转化为去氢表雄酮（dhea）（17，20-裂解酶活性）。cyp17缺乏同时累及肾上腺和性腺，有两种缺乏类型：①17a-羟化酶 ...

细胞色素 P450 17A1 （英語： Cytochrome P450 17A1）也被称为 甾体17α-单加氧酶 （steroid 17α-monooxygenase）， 17α-羟基化酶 （17α-hydroxylase）， 17,20-碳链裂解酶 （17,20-lyase 或 17,20-desmolase）是一种 羟基化 酶，由位于人类 10号染色体 的 CYP17A1 基因 编码 [6]。 这一基因在许多组织与细胞中都有表达，特别是 肾上腺皮质 的 网状带 （英语：zona reticularis） 和 肾上腺束状带 （英语：zona fasciculata） 以及 生殖腺 组织 [7][8]。

2024年12月24日 · CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP17A1 include Adrenal Hyperplasia, Congenital, Due To 17-Alpha-Hydroxylase Deficiency and 17 Alpha-Hydroxylase/17,20-Lyase Deficiency. Among its related pathways are Metabolism of steroid hormones and Metabolism of steroids.

细胞色素 P450 蛋白是单加氧酶，可催化许多涉及药物代谢和胆固醇、类固醇和其他脂质合成的反应。 该蛋白质定位于内质网。 它同时具有 17α-羟化酶和 17,20-裂解酶活性，是产生孕激素、盐皮质激素、糖皮质激素、雄激素和雌激素的类固醇生成途径中的关键酶。 该基因的突变与孤立的类固醇 17 α-羟化酶缺乏症、17-α-羟化酶/17,20-裂解酶缺乏症、假两性畸形和肾上腺增生有关。 [RefSeq 提供，2008 年 7 月] This gene encodes a member of the Cytochrome P450 …

2025年1月23日 · 阿比特龙(泽珂，醋酸阿比特龙片，Abiraterone，Zytiga)是一种口服有效的CYP17酶抑制剂，由强生公司（美国）精心研制开发。 此药物主要用于治疗转移性去势抵抗性前列腺癌（mCRPC），通过与泼尼松联用，能够显著延长…

2013年11月26日 · In this Review, we examine the hormone-based treatment of castration-resistant prostate cancer (CRPC) using inhibitors of steroid 17α-hydroxylase/C17,20-lyase (CYP17), of which abiraterone...

Dozens of mutations in the gene have been found to cause 17α-hydroxylase/17,20-lyase deficiency. This condition affects the function of certain hormone-producing glands, leading to high blood pressure (hypertension) and abnormal sexual development.

It is an atypical cytochrome P450 enzyme in that it catalyzes two distinct types of substrate oxidation. Through its hydroxylase activity, it catalyzes the 17α-hydroxylation of pregnenolone to 17α-OH pregnenolone.

Cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17) is a microsomal enzyme catalyzing two distinct activities, 17alpha-hydroxylase and 17,20-lyase, essential for the biosynthesis of adrenal and gonadal steroids. CYP17 is a potent oxidant, it is present in liver and nonsteroidogenic tissues, and …