Calcium/calmodulin-dependent protein kinase kinase 2 is an enzyme that in humans is encoded by the CAMKK2 gene. [5][6] The product of this gene belongs to the serine/threonine-specific protein kinase family, and to the Ca ++ / calmodulin-dependent protein kinase subfamily.

2024年12月24日 · CAMKK2 (Calcium/Calmodulin Dependent Protein Kinase Kinase 2) is a Protein Coding gene. Diseases associated with CAMKK2 include Parkinson Disease, Late-Onset and Wolff-Parkinson-White Syndrome. Among its related pathways are Calmodulin induced events and GPCR downstream signalling.

Calcium (Ca 2+) is an essential ligand that binds its primary intracellular receptor Calmodulin (CaM) to trigger a variety of downstream processes and pathways.

2021年9月25日 · CAMKK2 deletion suppressed cellular respiration in both cell types, shifting metabolic phenotype to aerobic glycolysis causing the Warburg effect. However, isolated mitochondria exhibited a cell-type-specific enhancement or dampening of the respiratory kinetics under CAMKK2 deletion conditions.

该基因的主要亚型通过磷酸化下游激酶 CaMK1 和 CaMK4，在钙/钙调蛋白依赖性 (CaM) 激酶级联中发挥作用。 该基因的蛋白质产物也磷酸化 AMP 活化蛋白激酶 (AMPK) 。 该基因在大脑中表达最强，并影响涉及学习和记忆、神经元分化和迁移、神经突生长和突触形成的信号级联。 可变剪接导致编码不同异构体的多个转录变体。 已鉴定的亚型在进行自身磷酸化和磷酸化下游激酶的能力方面存在差异。 [RefSeq 提供，2012 年 7 月]

Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) is a serine/threonine-protein kinase belonging to the Ca /calmodulin-dependent protein kinase subfamily. CAMKK2 has an autocatalytic site, which gets exposed when Ca /calmodulin (CAM) binds to it. This results in autophosphorylation and complete activation of CAMKK2.

钙/钙调蛋白依赖性蛋白激酶 II（CaM 激酶 II 或 CaMKII）是一种 丝氨酸 / 苏氨酸 特异性蛋白激酶，由钙/钙调蛋白复合物调节。 CaMKII 参与许多信号传导级联，被认为是学习和记忆的重要中介者。 [1] CaMKII 也对心肌细胞中的钙稳态和重吸收 [2] 、上皮细胞中的氯离子运输 [3] 、T细胞的正向选择 [4] 以及CD8 T细胞的激活 [5] 都是必须的。 CaMKII 的调控失常与阿尔茨海默病、安吉尔曼综合征和心律失常有关。 [6] CaMKII 的所有异构体都具有：催化域、自抑制域、可变段和自关 …

2025年3月8日 · Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation.

2022年10月29日 · Here, we identify calmodulin-dependent kinase kinase 2 (CaMKK2) as a driver of ICB resistance. CaMKK2 is highly expressed in pro-tumor cells and is associated with worsened survival in patients...

2020年11月2日 · Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) is a serine/threonine-protein kinase belonging to the Ca2+/calmodulin-dependent protein kinase subfamily. CAMKK2 has an autocatalytic site, which gets exposed when Ca2+/calmodulin (CAM) binds to it. This results in autophosphorylation and complete activation of CAMKK2.