Cadmium increased the mRNA levels of Bax gene compared to the control group at 2 and 4 mg/kg (P < 0.01) in small intestine of rats. The mRNA levels of Bcl-2 gene decreased …

2019年4月1日 · In this study, we hypothesized that reactive oxygen species (ROS)-mediated c-jun N-terminal kinase (JNK) signaling pathway was involved in cadmium-induced apoptosis in …

2019年1月1日 · Cadmium increased the ratio of pro-apoptotic Bax/anti-apoptotic Bcl-2 expression in human astrocytes. Cadmium caused S and G2/M phase cell cycle arrest in human …

2004年11月1日 · Previous reports have demonstrated that cadmium (Cd) may induce cell death via apoptosis, but the mechanism responsible for cellular death is not clear. In this study, we …

Death receptor marker tumor necrosis factor-α (TNF-α), executor caspase-8 and pro-apoptotic gene (Bax) were induced, while antiapoptotic gene (Bcl-2) was decreased in Cd-treated cells. …

2017年4月17日 · The present study showed that cadmium exposure leads to decreases in mRNA expression of anti-apoptotic Bcl-2, increases in that of pro-apoptotic Bax genes and decreases …

Increased levels of p53 and Bax are suggested to be involved in the apoptosis. The apoptosis did not appear to be mediated by oxidative pathways. The lung is a target organ for cadmium (Cd) …

Methods Real-time fluorescent quantitative reverse transcriptase polymerase chain reaction (QPCR) was used to detect the level of bal-2 and bax mRNA in 16HBE cells and cell …

One important aspect of this crosstalk is the involvement of proapoptotic proteins Bim and Bax, which are upregulated following acute cadmium exposure. Bax, in particular, translocates from …

The evidences indicate that cadmium induces aberrant gene expression, inhibition of DNA damage repair, and apoptosis. In this study, we investigated the effects of IP (intraperitoneal) …

Increased levels of p53 and Bax are suggested to be involved in the apoptosis. The apoptosis did not appear to be mediated by oxidative pathways. The lung is a target organ for cadmium (Cd) …

2004年4月1日 · Occupational cadmium exposure is associated with lung cancer in human. In the present study, we established the mechanistic basis of apoptotic cell death induced by Cd in …

Cadmium decreased Bcl-2 expression and increased Bax expression in both brain regions in a dose-dependent manner, reducing the Bcl-2/Bax ratio and inducing apoptosis through …

To investigate the underlying mechanism of neurotoxicity of cadmium, we examined the effects of intraperitoneal injection of cadmium on messenger RNA (mRNA) expression of Bcl-2 (B-cell …

2009年2月10日 · Inhibition of ERKs by prior treatment of cells with 10 μM U0126 relieves cadmium-mediated inhibition of apoptosis/bax induction/caspase-9 activation. Our results …

To investigate the underlying mechanism of neurotoxicity of cadmium, we examined the effects of intraper-itoneal injection of cadmium on messenger RNA (mRNA) expression of Bcl-2 (B-cell …

2017年4月17日 · Cadmium reduced the mRNA level of Bcl-2 in the control group at doses of 1 (p < 0.01), 2 and 4 mg/kg (p < 0.001) in rat hippocampus and cortex cells. The mRNA level of …

2021年1月1日 · The tumor suppressor p53 is involved in cadmium (Cd)-induced apoptosis and autophagy. However, the regulatory mechanisms of p53 in Cd-induced kidney injury are not …

To investigate the underlying mechanism of neurotoxicity of cadmium, we examined the effects of intraperitoneal injection of cadmium on messenger RNA (mRNA) expression of Bcl-2 (B-cell …

2021年1月1日 · In the current study, Cd-exposed HK-2 cells induced p53 and phospho-p53 and subsequently upregulated the pro-apoptotic protein BAX, indicating that p53 induced …