2024年12月24日 · Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca (2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and …

Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMKIIα), a.k.a. Ca 2+ /calmodulin-dependent protein kinase II alpha, is one subunit of CamKII, a protein kinase (i.e., an enzyme which phosphorylates proteins) that in humans is encoded by the CAMK2A gene.

2025年3月8日 · Camk2a suppresses denervated muscle atrophy by maintaining the Ca2+ homeostasis in muscle cells. Association of CaMK2A and MeCP2 signaling pathways with cognitive ability in adolescents. Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis.

2022年9月2日 · Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most abundant protein in excitatory synapses and is central to synaptic plasticity, learning and memory. It is...

The CAMK2A gene encodes a subunit of calcium/calmodulin-dependent protein kinase II (CaM kinase II, CAMK2), a multifunctional serine/threonine kinase that has critical roles in synaptic plasticity, learning, and memory, including long-term potentiation.

CAMK2 Therapeutics Network is a family-led, scientifically supported international collaboration working to improve the lives of individuals with CAMK2 genetic mutations. The rare gene mutations result in severe neurodevelopmental disorders that affect our loved ones and pose extreme challenges for family life.

2024年1月26日 · Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning.

2025年2月8日 · Enables calcium/calmodulin-dependent protein kinase activity; calmodulin binding activity; and glutamate receptor binding activity. Involved in several processes, including peptidyl-threonine autophosphorylation; regulation of endocannabinoid signaling pathway; and regulation of synaptic vesicle docking.

2019年7月10日 · Ca 2+ /calmodulin-dependent protein kinase II (CAMK2) is a key player in synaptic plasticity and memory formation. Mutations in Camk2a or Camk2b cause intellectual disability in humans, and severe plasticity and learning deficits in mice, indicating unique functions for each isoform.

2020年6月1日 · Calcium/Calmodulin dependent protein kinase II alpha (CAMK2A) is a key calcium signaling molecule activated by exogenous and endogenous stimuli with effects on multiple cell functions...