2024年12月24日 · CAMSAP3 (Calmodulin Regulated Spectrin Associated Protein Family Member 3) is a Protein Coding gene. Diseases associated with CAMSAP3 include Deafness, Autosomal Dominant 21 and Deafness, Autosomal Recessive 25. Among its related pathways is Stabilization and expansion of the E-cadherin adherens junction.

Calmodulin-regulated spectrin-associated protein family member 3 (CAMSAP3) is a human protein encoded by the gene CAMSAP3. The protein is commonly referred to as Nezha. CAMSAP3 acts as a minus-end anchor of microtubules, and binds to …

Broad expression in skin (RPKM 9.2), duodenum (RPKM 7.0) and 18 other tissues. 启用肌动蛋白丝结合活性和微管负端结合活性。 参与多个过程，包括微管细胞骨架组织；细胞器组织的调节；和 zonula 坚持维护。 位于细胞质中；核质；和粘附带。 与中心体和微管负端共定位。 [由基因组资源联盟提供，2022 年 4 月] Enables actin filament binding activity and microtubule minus-end binding activity.

2024年2月29日 · We found that all CAMSAPs could bind to the minus ends of γ-TuRC-attached microtubules. CAMSAP2 and CAMSAP3, which decorate and stabilize growing minus ends but not the minus-end tracking protein...

CAMSAP3 facilitates basal body polarity and the formation of the central pair of microtubules in motile cilia. Findings suggest that CAMSAP3 functions to protect lung carcinoma cells against EMT by suppressing Akt activity via microtubule regulation and that CAMSAP3 loss promotes EMT in these cells.

2024年2月1日 · In this study, we identified microtubule-bound CAMSAP3 within HaCaT keratinocytes, revealing an upregulation during the mitotic phase and accumulation at the intercellular bridge during cytokinesis.

Our study demonstrates that in intestinal epithelial cells, the microtubule minus-end binding protein CAMSAP3 (calmodulin-regulated–spectrin-associated protein 3) tethers noncentrosomal microtubules to the apical cortex, leading to their longitudinal orientation.

2024年12月1日 · Our study reveals that CAMSAP3 forms dimers through its C-terminal α-helix; this dimerization not only enhances the microtubule-binding affinity of the CKK domain but also enables the CKK domain to regulate the dynamics of microtubules.

2024年6月1日 · CAMSAP3 is prerequisite for TSA-mediated autophagic cell death by interacting with cytoplasmic acetylated HMGB1 and enhancing its release. This finding provides molecular insights into the role of CAMSAP3 in regulating cell death, highlighting its potential as a therapeutic target for lung cancer treatment.

2018年9月25日 · Here we show that CAMSAP3 (calmodulin-regulated spectrin-associated protein 3), a protein that regulates the minus-end dynamics of microtubules, plays a key role in maintaining neuronal polarity. In mouse hippocampal neurons, CAMSAP3 was enriched in axons.