2024年12月24日 · CAPN2 (Calpain 2) is a Protein Coding gene. Diseases associated with CAPN2 include Oculopharyngodistal Myopathy 2 and Amelogenesis Imperfecta, Hypomaturation Type, Iia2. Among its related pathways are Defective Intrinsic Pathway for Apoptosis and DREAM Repression and Dynorphin Expression.

CAPN2 conferred gefitinib‑resistance by inhibiting cell apoptosis and arresting the cell cycle. CAPN2 knockdown also induced caspase activation and mitochondrial dysfunction, and its function in gefitinib resistance appeared to be largely mediated by EGFR/protein kinase B/survivin signaling pathway activation.

Calpain-2 catalytic subunit is a protein that in humans is encoded by the CAPN2 gene. [5][6] The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins.

2024年11月27日 · Title: CAPN2 promotes apalutamide resistance in metastatic hormone-sensitive prostate cancer by activating protective autophagy. Rare variants in CAPN2 increase risk for isolated hypoplastic left heart syndrome.

2025年2月8日 · CAPN2 acts as an indicator of hepatitis B virus to induce hepatic fibrosis. Calpain-2 participates in the process of calpain-1 inactivation. Heat stress reduces calpain-2 expression, which then activates p38, leading to cardiomyocyte apoptosis and heart dysfunction.

CAPN2 exhibited a significant overexpression in human RCC tissues and cell lines compared with adjacent non-tumor tissues and normal human proximal tubule epithelial cell line HK-2. Strong staining of CAPN2 was associated with higher clinical stage and histological grade.

2022年8月19日 · We showed that transgenic mice over-expressing calpain-2 restricted to cardiomyocytes had normal heart function with no evidence of cardiac pathological remodeling at age 3 months.

钙蛋白酶是钙激活的中性蛋白酶，是非溶酶体细胞内半胱氨酸蛋白酶。 哺乳动物钙蛋白酶包括普遍存在的胃特异性和肌肉特异性蛋白质。 无处不在的酶由异二聚体组成，这些异二聚体具有与共同的小调节亚基相关联的独特的大催化亚基。 该基因编码普遍存在的酶钙蛋白酶 2 的大亚基。 已报道 5' UTR 中的多个异质转录起始位点。 已发现该基因的两个转录本变体编码不同的亚型。 [RefSeq 提供，2009 年 3 月] The calpains, calcium-activated neutral proteases, are nonlysosomal, …

2024年10月6日 · Clinical resource with information about CAPN2, Common variants associated with general and MMR vaccine-related febrile seizures., and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

二、capn2：隐藏在细胞深处的“多面手”靶点. capn2属于钙蛋白酶家族，是一种钙依赖性、非溶酶体半胱氨酸蛋白酶。它在细胞中身兼数职，是细胞骨架重塑与信号转导的“调节者”，通过有限蛋白水解作用，分解关键底物，调节细胞的结构和功能。