
Caspr1 is a host receptor for meningitis-causing - Nature
2018年6月12日 · Here, we identify Caspr1, a single-pass transmembrane protein, as a host receptor for E. coli virulence factor IbeA to facilitate BBB penetration. Genetic ablation of endothelial Caspr1 and...
CASPR - Wikipedia
CASPR also known as Contactin associated protein 1, Paranodin and CASPR1 is a protein that in humans is encoded by the CNTNAP1 gene. [5] CASPR is a part of the neurexin family of proteins, hence its another name " Neurexin IV ". [6]
Antibodies to the Caspr1/contactin-1 complex in chronic
2021年5月7日 · Previous studies have described the clinical, serological and pathological features of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and antibodies directed against the paranodal proteins neurofascin-155, contactin-1 (CNTN1), contactin-associated protein-1 (Caspr1), …
Caspr1 is a host receptor for meningitis-causing Escherichia coli
2018年6月12日 · Here, we identify Caspr1, a single-pass transmembrane protein, as a host receptor for E. coli virulence factor IbeA to facilitate BBB penetration. Genetic ablation of endothelial Caspr1 and blocking IbeA-Caspr1 interaction effectively prevent E. coli penetration into the brain during meningitis in rodents.
Antibodies to the Caspr1/contactin-1 complex in chronic …
2021年4月20日 · Contactin-associated protein 1 (Caspr1) is a cell-adhesion protein expressed by neurons. 21,22 Caspr1 forms a complex with CNTN1 23,24 that binds to the glial protein NF155, which together form the septate-like junctions (transverse bands) that interconnect the paranodal loops of Schwann cells to the axon at the paranode.
Structure and function of the contactin-associated protein family …
The contactin-associated protein (Caspr) family participates in nerve excitation and conduction, and neurotransmitter release in myelinated axons. We analyzed the structures and functions of the Caspr family–CNTNAP1 (Caspr1), CNTNAP2 (Caspr2), ...
Caspr1 Facilitates sAPPα Production by Regulating α-Secretase …
In this study, we found Caspr1 depletion reduced the levels of soluble amyloid protein precursor α (sAPPα) in the supernatant of HBMECs, which could be rescued by expression of full-length Caspr1. Our further results showed that ADAM9, the α-secretase essential for processing of APP to generate sAPPα, was decreased in Caspr1-depleted HBMECs.
Contactin-associated Protein 1 (Caspr1) Regulates the Traffic …
We identify Contactin-associated protein 1 (Caspr1) as an AMPA receptor interactor. Caspr1 is present in synapses and interacts with AMPA receptors in brain synaptic fractions. Coexpression of Caspr1 with GluA1 increases the amplitude of glutamate-evoked currents.
Contactin -Associated protein1 Regulates Autophagy by …
2024年8月20日 · Contactin-associated protein1 (Caspr1) plays an important role in the formation and stability of myelinated axons. In Caspr1 mutant mice, autophagy-related structures accumulate in neurons, causing axonal degeneration; however, the mechanism by which Caspr1 regulates autophagy remains unknown.
A CASPR1–ATP1B3 protein interaction modulates plasma …
Contactin-associated protein 1 (CASPR1 or CNTNAP1) was recently reported to be expressed in brain microvascular endothelial cells (BMECs), the major component of the blood–brain barrier. To investigate CASPR1's physiological role in BMECs, here we ...