Our results showed that the expression of calcium-sensing receptor (CaSR) and the concentration of intracellular calcium were enhanced in the osteosarcoma cells MG-63 compared with in the normal osteoblasts hFOB1.19. GdCl 3 (CaSR agonist) significantly increased the proliferation rate of …

2015年8月31日 · The extracellular calcium-sensing receptor (CaSR) is a G-protein coupled receptor that monitors the systemic extracellular free ionized calcium level ([Ca 2+] o) in organs involved in systemic [Ca 2+] o homeostasis. CaSR is widely expressed in the nervous system and its activation promotes axon and dendrite growth during development, but the ...

2018年4月9日 · The two crucial dysregulations in ADPKD, intracellular calcium and cAMP levels, are two pathways both regulated in the kidney by the activation of the extracellular calcium-sensing receptor...

2017年8月1日 · Activation of the G protein-coupled calcium-sensing receptor (CaSR) has crucial roles in skeletal development and bone turnover. Our recent study has identified a role for activated CaSR in the osteogenic differentiation of human periodontal ligament stem cells.

2013年6月1日 · The CaSR activates various protein kinases including conventional isoforms of PKC, downstream of PI-PLC and Ca 2+ i mobilization, as well as mitogen-activated protein (MAP) kinases including ERK 1/2, p38, and JNK (reviews 11, 82) and two key protein kinase regulators of cell fate, Akt and GSK-3. 121 The CaSR also couples to Rho kinase under the ...

我们的研究结果表明，casr 通过增强 casr-pkc-erk1/2 通路加速海马神经元凋亡和降低突触可塑性，从而对 cih 诱导的小鼠认知功能障碍发挥关键作用；否则，抑制 casr 可减轻 cih 引起的认知功能障碍。

CaSR的激动剂CaCl2可进一步增强低氧引起的上述作用（P＜0.05），而转染CaSR-siRNA及给予ERK信号通路特异性抑制剂U0126可抑制低氧引起的上述效应（P＜0.05）。 结论 CaSR可通过MEK/ERK1/2信号通路参与低氧诱导的气道黏液高分泌。 Abstract: Objectlve To explore the signal pathway of calcium-sensing receptor (CaSR) in hypoxia-induced airway mucous hypersecretion.

2023年12月18日 · 钙离子敏感受体 （casr） 是c家族g蛋白偶联受体 （gpcr） 的一员，广泛分布于甲状旁腺、肠道、骨骼和肾脏等组织器官中。 casr 感应血液中钙离子的浓度，并通过平衡钙离子的吸收和外排从而维持人体中的钙离子平衡。由于钙离子参与信号传递、凝血、肌肉收缩 ...

The extracellular calcium-sensing receptor (CaSR) is a G-protein coupled receptor that monitors the systemic extracellular free ionized calcium level ([Ca 2+] o) in organs involved in systemic [Ca 2+] o homeostasis. CaSR is widely expressed in the nervous system and its activation promotes axon and dendrite growth during development, but the ...

研究不同浓度钙离子对人成骨样细胞MG-63分化的影响.结果表明, 5.0mmol/L Ca 2+ 促进 CaSR、ALP、OC、Runx 2、IGF-1和BMP2 mRNA表达,而加入CaSR和ERK抑制剂后,则下调 ALP、OC、Runx 2、IGF-1和BMP2 mRNA表达.不同浓度Ca 2+ 处理后,磷酸化-ERK(p-ERK)蛋白表达明显增加.因此,5.0mmol/L Ca 2+ 通过 ...