Targeting Cathepsin C in PR3-ANCA Vasculitis - PubMed
Cathepsin C (CatC) from zymogens activates the proteolytic function of NSPs, including PR3. Lack of NSP zymogen activation results in neutrophils with strongly reduced NSP proteins.
Cathepsin C inhibition reduces neutrophil serine protease ... - Nature
2024年8月22日 · We demonstrate that a CatC inhibitor, MOD06051, dose-dependently suppresses the cellular activity of NSPs, including neutrophil elastase (NE), in vitro. …
Cathepsin C inhibition as a potential treatment strategy in cancer
2021年12月1日 · The authors argue that the tumor CatC-mediated activation of PR3 mb resulted in IL-1β processing and NFκb activation in the neutrophils. In the proposed scheme, this …
BI 1291583: a novel selective inhibitor of cathepsin C with
Results: BI 1291583 bound human CatC in a covalent, reversible manner, selectively and fully inhibiting CatC enzymatic activity. This inhibition translated to concentration-dependent …
Targeting Cathepsin C in PR3-ANCA Vasculitis - LWW
We explored CatC as a potential AAV treatment target to downregulate NSPs, including the PR3 autoantigen that drives PR3-AAV. Our study revealed several new findings. First, human CatC …
Consequences of cathepsin C inactivation for membrane exposure …
2018年8月8日 · PR3 and related proteases are activated from pro-forms by the lysosomal cysteine protease cathepsin C (CatC) during neutrophil maturation. We hypothesized that …
Pharmacological inhibition of cathepsin S and of NSPs-AAP-1 (a …
2024年11月1日 · This CatC-like protease(s), now called NSPs-Alternative Activating Protease-1 (NSPs-AAP-1), was capable of activating 80 % of PR3 and CatG when proCatC maturation …
Consequences of cathepsin C inactivation for membrane …
2018年8月10日 · PR3 and related proteases are activated from pro-forms by the lysosomal cysteine protease cathepsin C (CatC) during neutrophil maturation. We hypothesized that …
Novel cathepsin C inhibitor, BI 1291583, intended for treatment of ...
2024年8月22日 · Cathepsin C (CatC) inhibition promises to achieve this through reduction of neutrophil-derived serine protease (including neutrophil elastase [NE] and proteinase 3 [PR3]) …
Pharmacological Cathepsin C Inactivation Eliminates Proteinase 3, …
2018年4月1日 · PR3 and related neutrophil serine proteases (NSP) are activated from proforms by the lysosomal cysteine protease cathepsin C (CatC) during neutrophil maturation. We …