Multi-omic profiling of clear cell renal cell carcinoma identifies ...
2024年2月15日 · Clear cell renal cell carcinoma (ccRCC) is a complex disease with remarkable immune and metabolic heterogeneity. Here we perform genomic, transcriptomic, proteomic,...
Integrative genomic study of Chinese clear cell renal cell …
2020年2月6日 · Our analysis reveals that a mutational signature associated with aristolochic acid (AA) exposure is widespread in Chinese ccRCC. Tumors from patients with ccRCC-TT show a …
论文解读丨Yuan Zhang/QingLiu He教授团队新研究揭示肾透明细 …
2024年6月4日 · 肾透明细胞癌（ccRCC）作为肾癌的主要亚型，因其治疗抵抗性和高复发率一直是医学研究的热点和难点。 鉴于对传统放化疗的不敏感性，靶向治疗和免疫疗法成为治 …
学术前沿 | 单细胞多组学分析揭示肾透明细胞癌关键转录因子调控 …
肾透明细胞癌 （clear cell renal carcinoma, ccRCC）是肾细胞癌中最常见的病理亚型 [1]。 由于其高度复杂的肿瘤微环境异质性，现有的临床干预策略，例如靶向治疗和免疫治疗等均未能取得 …
Renal tumors with different histological types occurring in the …
2025年3月1日 · An 84-year-old male with two right renal tumors underwent radical nephrectomy. Pathology revealed chromophobe renal cell carcinoma (ChRCC) and clear cell renal cell …
LRRK2 reduces the sensitivity to TKI and PD-1 blockade in ccRCC …
4 天之前 · LRRK2 is transcriptionally upregulated by HIF2A and enhances ccRCC proliferation in a kinase-independent manner. We attempted to identify novel protein kinase candidates for …
DASNet: A Convolutional Neural Network with SE Attention
2 天之前 · Clear cell renal cell carcinoma (ccRCC) is the most common form of renal cell carcinoma in adults, comprising approximately 80% of cases. The lethality of ccRCC rises …
Identification of clear cell renal cell carcinoma subtypes by ...
2024年6月15日 · ccRCC is a highly heterogeneous tumor and the most common subtype of renal cell carcinoma (RCC) [18]. The identification of cancer subtypes contributes to a deeper …
Tracking Nongenetic Evolution from Primary to Metastatic ccRCC: …
2025年3月3日 · Clear-cell renal cell carcinomas (ccRCC) frequently exhibit genetic intratumor heterogeneity (ITH) that can fuel disease evolution ().In the context of the ongoing TRACERx …
Study on the mechanism of BGN in progression and metastasis of ccRCC
2025年3月19日 · Clear cell renal cell carcinoma (ccRCC) is the predominant histological subtype of renal cell carcinoma (RCC), representing approximately 75% of all RCC cases, which is a …
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