The m6A modification-mediated OGDHL exerts a tumor …
2023年8月25日 · Mechanistic studies revealed that FTO inhibits OGDHL expression in ccRCC through RNA m6A methylation, which downregulates FASN, leading to lipid accumulation and ERK pathway activation.
METTL14-mediated N6-methyladenosine modification of Pten …
2022年3月5日 · Clear-cell renal-cell carcinoma (ccRCC) is one of the leading causes of tumour-related death worldwide. Methyltransferase-like 14 (METTL14) is reported...
VHL governs m6A modification and PIK3R3 mRNA stability in
2024年4月15日 · N6-Methyladenosine (m6A), a prevalent posttranscriptional modification, plays an important role in cancer progression. Clear cell renal cell carcinoma (ccRCC) is chiefly associated with the loss of the von Hippel-Lindau (VHL) gene, encoding a component of the E3 ubiquitin ligase complex. In this iss …
Gene signatures and prognostic values of m6A regulators in clear …
It is plausible that VHL-HIF-METTL3/14 pathways are involved in the m6A regulation in ccRCC cancer cells, and PI3K-mTOR as well as p53 signaling pathways are possible downstream targets of m6A in ccRCC.
Von Hippel Lindau tumor suppressor controls m6A-dependent …
2024年4月15日 · Evidence suggests that the dysregulated N6-methyladenosine on RNA (m6A) is involved in the initiation and progression of renal cancers , suggesting a potential therapeutic opportunity for ccRCC. The m6A represents a most prevalent modification of mRNA in …
A signature based on m6A pattern and tumor microenvironment …
2022年7月15日 · Background: RNA N6-methyladenosine (m6A) has been found to have a critical impact on clear cell renal cell carcinoma (ccRCC) by affecting the tumor microenvironment (TME) and immune cell (IC) infiltration and is related to the …
Gene signatures and prognostic values of m6A regulators in clear …
2019年3月3日 · m6A is the most common form of mRNA modification. However, little is known about its role in clear cell renal cell carcinoma (ccRCC). This study aims to identify gene signatures and prognostic values of m6A regulators in ccRCC. In this study, a total of 528 ccRCC patients from TCGA database with sequencing and CNV data were included.
DMDRMR-Mediated Regulation of m6A-Modified CDK4 by m6A …
2021年2月15日 · In patients with ccRCC, high coexpression of DMDRMR and IGF2BP3 was associated with poor outcomes. Our findings reveal that DMDRMR cooperates with IGF2BP3 to regulate target genes in an m 6 A-dependent manner and may represent a potential diagnostic, prognostic, and therapeutic target in ccRCC.
revealed that FTO inhibits OGDHL expression in ccRCC through RNA m6A methylation, which downregulates FASN, leading to lipid accumulation and ERK pathway activation. We propose that
N6-methyladenosine (m6A) reader IGF2BP1 facilitates clear-cell …
In this study, we identified that the novel m6A reader IGF2BP1 up-regulated in the ccRCC and functional analysis determined its oncogenic role in ccRCC. Notably, IGF2BP1 targeted the LDHA mRNA to enhance LDHA mRNA stability, thereby promoting ccRCC aerobic glycolysis.