CD30, also known as TNFRSF8 (TNF receptor superfamily member 8), [5] is a cell membrane protein of the tumor necrosis factor receptor family and a tumor marker. This receptor is expressed by activated, but not by resting, T and B cells.

Fibrous breast capsule with mild chronic inflammation No morphologic or immunophenotypic support for lymphoma Histologic sections of the right breast capsule show a fibrinous breast capsule with scattered small and mature lymphocytes. Synovium-like lining formation and silicone particles are occasionally seen.

2017年9月8日 · CD30 is a member of the tumor necrosis factor receptor superfamily. It is characteristically expressed in certain hematopoietic malignancies, including anaplastic large cell lymphoma and...

CD30, also known as TNFRSF8 (tumor necrosis factor receptor superfamily member 8), is a protein receptor that is heavily glycosylated inside the Golgi apparatus, as well as a tumor marker that is found on the surface of specific cells in the body, …

2021年5月6日 · Member of tetraspanin family (members have 4 hydrophobic domains, others are CD9, CD53, CD63, CD81, CD82 and CD151) Regulates T cell proliferation (J Immunol 2004;172:2953) Clinical features: inhibits IgA responses and regulates the anti-fungal immune response (PLoS Pathog 2009;5:e1000338) No significant clinical use by pathologists

CD30 was originally described as a marker of Hodgkin's and Reed-Sternberg cells in Hodgkin's lymphoma. Cloning and characterization of cDNAs encoding CD30 and its ligand (CD30L) established these proteins as members of the tumor necrosis factor receptor (TNFR) and tumor necrosis factor (TNF) superfamilies, respectively.

CD30 is a cell surface receptor expressed in classical Hodgkin lymphoma (HL), anaplastic large cell lymphoma (ALCL), and many other lymphomas to a variable degree. It has been identified as an important therapeutic target in lymphoma.

2022年3月29日 · CD30, encoded by TNFRSF8, is a transmembrane cytokine receptor of the tumor necrosis factor receptor (TNFR) superfamily and expressed on ~20% of DLBCL. To better understand the underlying...

2022年5月17日 · CD30抗原是一个120kDa的跨膜糖蛋白，具有细胞内结构域、跨膜结构域、细胞外结构域。 CD30基因属于肿瘤坏死因子受体（tumor necrosis factor receptor，TNFR）超家族成员，与其他的TNFR成员在细胞外结构域方面具有序列同源性，均包括了6个富于半胱氨酸的重复序列，因此该分子又称为肿瘤坏死因子受体超家族成员8（tumor necrosis factor receptor superfamily member 8，TNFRSF8）或CD153。 正如所料，目前已确定膜性CD30配体与肿瘤坏死因子家 …

2022年5月23日 · 最近的多中心研究得出结论，CD30共表达的弥漫大B细胞淋巴瘤是和CD30阴性弥漫大B细胞淋巴瘤不同的特殊分子类型，临床预后也有所不同。 不管细胞来源如何（生发中心型、活化B细胞型），CD30阳性弥漫大B细胞淋巴瘤的总体预后、无进展预后都优于CD30阴性弥漫大B细胞淋巴瘤。 弥漫大B细胞淋巴瘤中已发现有大量分子遗传学改变及突变。 遗传学谱系的差异，进一步支持CD30阳性、CD30阴性弥漫大B细胞淋巴瘤属于不同病种的概念。 不管世界卫生 …