Semaphorin-4D (SEMA4D) also known as Cluster of Differentiation 100 (CD100), is a protein of the semaphorin family that in humans is encoded by the SEMA4D gene. [5]

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cd100. 轴突导向因子 4d、sema4d. 白细胞和少突胶质细胞。 削弱单核细胞迁移、激活 b 细胞和 t 细胞、参与 b 细胞与 t 细胞相互作用、以及参与 t 细胞与树突细胞相互作用。 cd101. igsf2、ewi101. 单核细胞、粒细胞、树突细胞、激活的 t 细胞和朗格汉斯细胞。

2022年4月26日 · SEMA4D（轴突导向蛋白4D，又称为CD100），是分子量为150 kDa的跨膜型同源二聚体蛋白，且为脑信号蛋白（Semaphorins）家族的重要成员之一 [2]。 SEMA4D分子结构主要包括：SEMA结构域、富含半胱氨酸结构域（cysterine-rich domain，CRD）和免疫球蛋白结构域（immunolobulin，Ig）（图1） [3]。 SEMA和CRD结构域为Semaphorins家族所共有的结构。 SEMA结构域不仅是SEMA4D蛋白进行信号转导的分子基础，且决定了反应的特异性。 CRD …

2024年12月25日 · SEMA4D (Semaphorin 4D) is a Protein Coding gene. Diseases associated with SEMA4D include Cholangitis, Primary Sclerosing and Ovarian Cancer. Among its related pathways are Semaphorin interactions and Nervous system development.

2020年12月18日 · Semaphorin 4D (SEMA4D), also known as CD100, is an important member of the semaphorin family and was first characterized as a lymphocyte-specific marker. SEMA4D has diverse effects on immunologic processes, including immune cell proliferation, differentiation, activation, and migration, through binding to its specific membrane receptors CD72 ...

SEMA4D/CD100 is a homodimeric protein belonging to the semaphorin family of axonal guidance proteins. Semaphorin family members have received increased attention lately due to their diverse functions in the immune system. SEMA4D was the first semaphorin described to have immune functions and serves …

This is the first example indicating that Sema 4D/CD100 is not only a ligand for plexin B1 or CD72 but also a direct signaling receptor in mediating Sema 4D/CD100-plexin B's biological functions. It is not surprising to identify Sema 4D/CD100-plexin B as a counter-receptor, because many counter-receptors have already been well documented in the ...

CD100, also known as Sema4D, is a member of the semaphorin family and has important regulatory functions that promote immune cell activation and responses. The role of CD100 expression on B cells in immune regulation during chronic hepatitis C virus (HCV) infection remains unclear.

Herein we describe the molecular characterization of the human leukocyte activation antigen CD100 and identify it as the first semaphorin, to our knowledge, in the immune system. Semaphorins have recently been described as neuronal chemorepellants that direct pioneering neurons during nervous system development.