细胞毒T淋巴细胞相关 抗原 4（cytotoxic T lymphocyte-associated antigen-4, CTLA-4）又名CD152，是一种 白细胞分化抗原 ，是T细胞上的一种跨膜受体，与CD28共同享有B7分子配体，而CTLA-4与B7分子结合后诱导T细胞无反应性，参与 免疫反应 的负调节。

Cytotoxic T-lymphocyte associated protein 4, (CTLA-4) also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses.

ATOR-1015是抗OX40/CTLA-4双特异性抗体，与调节性T细胞（抑制免疫系统的细胞）上的CTLA-4和OX40结合，激活巨噬细胞以杀死Treg，消除Treg对有益T细胞的抑制作用，同时效应T细胞（浅绿色）数量成倍增加并被激活以杀死肿瘤细胞。 和铂医药的HBM4003是通过自有HCAb技术平台开发的全人源仅含重链可变区的抗CTLA-4单克隆抗体，经过工程改造，可显着增强ADCC并增加Treg细胞耗竭。 作为与免疫检查点PD-1齐名的CTLA-4，两者的开发有很多共性：比方说适应 …

细胞毒T淋巴细胞相关抗原4（cytotoxic T lymphocyte-associated antigen-4, CTLA-4）又名CD152，是一种白细胞分化抗原，是T细胞上的一种跨膜受体，与CD28共同享有 B7分子配体 ，而CTLA-4与B7分子结合后诱导T细胞无反应性，参与免疫反应的负调节。基因重组的CTLA-4 Ig可在 …

CTLA4 又稱 CTLA-4 （細胞毒性T淋巴細胞相關抗原4，cytotoxic T-lymphocyte-associated protein 4）或 CD152 （分化群 152），是一种 蛋白质受体 [7]。 CTLA-4蛋白由小鼠的Ctla4 [8] 和人类的CTLA4基因编码 [9]。 CTLA-4于1991年首次被發現 [10]。 ^ 與細胞毒性T淋巴細胞相關抗原4相關的疾病；在維基數據上查看/編輯參考. ^ 對細胞毒性T淋巴細胞相關抗原4起作用的藥物；在維基數據上查看/編輯參考. ^ Human PubMed Reference:.

Cytotoxic T lymphocyte antigen-4 (CTLA-4, CD152) is a 25 kDa molecule composed of a leader peptide, a ligand binding domain, a transmembrane domain, and a cytoplasmic domain. Three isoforms are generated through gene splicing in humans: full-length CTLA-4, soluble CTLA-4, and exon 1 and exon 4 forms ( Ling et al., 1999 ; Valk et al., 2008 ).

2024年12月24日 · CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) is a Protein Coding gene. Diseases associated with CTLA4 include Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation and Celiac Disease 3. Among its related pathways are Gene expression (Transcription) and CD28 co-stimulation.

CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring PI3 kinase function

Coreceptor-based immunotherapy is a rapidly developing approach to treat cancer patients. Among those targeted receptors, CTLA-4 is the primary attenuator of adaptive immune responses and the most prominent and extensively investigated molecule in this field.

CTLA-4 (CD152), the CD28 homologue, is a costimulatory molecule with negative effects on T cell activation. In addition to its role in the termination of activation, CTLA-4 has been implicated in anergy induction and the function of regulatory ...