Invitrogen Anti-CD194 (CCR4) Monoclonal (D8SEE), eBioscience™, Catalog # 17-1949-42. Tested in Flow Cytometry (Flow) applications. This antibody reacts with Human samples. Supplied as 100 Tests purified antibody (5 µL/Test).

2024年12月24日 · CCR4 (C-C Motif Chemokine Receptor 4) is a Protein Coding gene. Diseases associated with CCR4 include Mycosis Fungoides and Peripheral T-Cell Lymphoma. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

CD194, also known as CCR4, is a CC chemokine receptor. It binds CCL17 and CCL22 and is expressed on a subset of T and B cells, basophils, monocytes, and NK cells. Human Th2 cells are characterized by the expression of CCR4 and CCR8, and these receptors are regulated differently during Th2 development.

The chemokine receptor CCR4 is a seven trans-membrane G protein-coupled cell surface receptor molecule (alternatively designated CD194) with selective expression on cells of the hematopoietic system (reviewed in 1, 2).

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G (i) proteins which activate a phosphatidylinositol-calcium second messenger system.

2024年4月22日 · The CCR4 (β-chemokine/C-C chemokine receptor type 4) is a cell surface receptor encoded by its related gene and is also a cluster of differentiation (CD194) . It is a G-protein-coupled receptor (GPCR) for signal transduction, causing cell activation and chemotaxis ( …

A gene on chromosome 3p24 that encodes a G protein-coupled receptor for C-C-type chemokines (MIP-1, RANTES, TARC and MCP-1). CCR4 is a high-affinity receptor for the C-C-type chemokines CCL17/TARC and CCL22/MDC; its activity is mediated by Gi proteins, which activate phosphatidylinositol-calcium second messengers.

The 1G1 monoclonal antibody specifically binds to CD194, also known as the human CC Chemokine Receptor type 4 (CCR4). CCR4 is expressed on activated Th2 cells, regulatory T cells, activated NK cells, basophils, monocytes and platelets. CCR4 is a seven-transmembrane, G-protein-coupled receptor, and is the specific receptor for CC chemokines, …

These antibodies target CCR4 in Human, Mouse, Rat, Non-human primate and Feline samples. Our CCR4... Antibodies that detect CCR4 can be used in several scientific applications, including Immunohistochemistry, Western Blot, ELISA, Flow Cytometry and Immunocytochemistry.

CD194 is the specific receptor for the chemokines CCL17 (TARC) and CCL22 (MDC). Human peripheral blood regulatory T cells can be divided into two distinct populations based on the expression of CCR4.