Use of CD200 blockade inhibitor to enhance glioma …
2015年11月4日 · We determinerd that CD200/CD200R interactions upregulate peptidylprolyl isomerase A (PPIA) inhibiting the production of TNF-α and IL-2, induces the formation of …
The CD200–CD200R1 Inhibitory Signaling Pathway
The CD200:CD200R1 inhibitory signaling pathway has been implicated in playing a prominent role in limiting inflammation in a wide range of inflammatory diseases. CD200R1 signaling …
Signaling by the inhibitory receptor CD200R is rewired by type …
2021年10月12日 · CD200 receptor 1 (CD200R) is an inhibitory immunoreceptor that suppresses Toll-like receptor (TLR)–induced cytokine production through the adaptor protein Dok2 and the …
CD200 Checkpoint Reversal: A Novel Approach to Immunotherapy
2020年1月3日 · We determined that targeting the CD200 activation receptors (CD200AR) of the CD200 checkpoint with a peptide inhibitor (CD200AR-L) overcomes tumor-induced …
CD200:CD200R Interactions and Their Importance in Immunoregulation …
2021年2月5日 · Interestingly, while expression of CD200 rapidly decreases using treatment with the MEK inhibitor (UO126), resistance develops to this treatment, consistent with the idea of …
CD200 in CNS tumor-induced immunosuppression: the role for CD200 …
2014年12月16日 · CD200-derived peptides were used as competitive inhibitors in a mouse model of glioblastoma immunotherapy. CD200 mRNA levels were measured in human brain tumors, …
Different mechanisms of CD200-CD200R induce diverse
2023年11月1日 · One model captures the tumor inhibition by CD200-CD200R in melanoma by including the anti-cancer reactions: (i) CD200-CD200R inhibits the expression of CCL8 …
CD200/CD200R: Bidirectional Role in Cancer Progression and ...
Through this CD200/CD200R signaling pathway, CD200 exerts its immunosuppressive effects by inhibiting natural killer (NK) cell activation, cytotoxic T cell functions, and M1-polarized …
CD200/CD200R paired potent inhibitory molecules regulating ... - PubMed
CD200/CD200R are required for maintaining self-tolerance. Many studies have demonstrated the importance of CD200 in controlling autoimmunity, inflammation, the development and spread …
The CD200-CD200R1 inhibitory signaling pathway: immune
The CD200:CD200R1 inhibitory signaling pathway has been implicated in playing a prominent role in limiting inflammation in a wide range of inflammatory diseases. CD200R1 signaling …