CD24：巨噬细胞检验点的明日之星 2020年11月， 默沙东 宣布以4.25亿美元现金预付款收购OncoImmune的CD24-Fc…
2022年11月12日 · 2020年11月，默沙东宣布以4.25亿美元现金预付款收购OncoImmune的CD24-Fc，这一收购决定是源于CD24-Fc在治疗新冠重症的中期分析中表现出良好的疗效。OncoImmune的创始人为马里兰大学医学院的华人科学家刘阳、郑盼夫妇。
CD24Fc ameliorates immune-related adverse events while
2022年7月15日 · The CD24–Siglec 10/G interaction constitutes an innate checkpoint that regulates inflammation triggered by danger-associated molecular patterns (DAMPs) 2, 3, 4 and cancer pathogenesis. 5 We...
Recombinant Human CD24 Fc Chimera Protein, CF - R&D …
CD24, also known as Heat-Stable Antigen and Nectadrin, is a heavily and variably glycosylated 30 kDa ‑ 60 kDa GPI-linked sialoprotein (1 - 4). Human CD24 is expressed on B lineage cells and granulocytes, on epithelial, neuronal, and muscle cells, and on a range of tumor cells (4 - 6).
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CD24-Fc resolves inflammation and rescues CD8 T cells with ...
2024年12月16日 · Our findings show that CD24-Fc treatment significantly reduced inflammation and immune hyperactivation in vivo when combined with cART. CD24-Fc mediated resolution of inflammation was associated with improved recovery of CD4 T cells, reduced immune activation, restored central memory T cells and reversal of immune cell exhaustion phenotype.
Novel insights into the function of CD24: A driving force in cancer
2021年2月1日 · In the present review, we summarize recent progress on the role of the CD24-Siglec-10 binding axis at the interface between tumor cells and the immune system, and the role of CD24 genetic polymorphisms in cancer. We describe the specific function of cytoplasmic CD24 and discuss the presence of CD24 on tumor-released extracellular vesicles.
金斯瑞解读｜肿瘤免疫治疗领域的新秀-CD24 - 百家号
2021年1月13日 · CD24-Fc用于免疫治疗可引起表达siglec10的免疫细胞(T细胞、B细胞、吞噬细胞)的免疫抑制，从而保护自身免疫。在癌症环境中，这可能是有害的。然而，CD24-Fc也可能作为CD24-Siglec10相互作用的可溶性抑制剂（来源：Int J Cancer）
Novel insights into the function of CD24: A driving force in cancer
2020年8月13日 · In metastatic melanoma, CD24-Fc is being tested for safety and efficacy in combination with the checkpoint inhibitory mAbs ipilimumab and nivolumab, to reduce the toxicity of immunotherapy. In addition, a phase Ib/II study plans to investigate the use of CD24-Fc in combination with ipilimumab or nivolumab for renal cell carcinoma and colon cancer.
CD24Fc protects against viral pneumonia in simian ... - Nature
2020年5月7日 · CD24Fc protects SIV-infected Chinese rhesus monkeys from viral pneumonia. a Experimental protocol. The timeline of the study activities is shown at the top. The rhesus monkeys were randomized...
Insights into CD24 and Exosome Physiology and Potential Role in …
A recombinant fusion protein composed of the extracellular domain of soluble CD24 linked to a human immunoglobulin G1 (IgG1) Fc domain, named CD24Fc, has been identified as a potential immune checkpoint inhibitor with anti-inflammatory properties.
CD24-Fc resolves inflammation and rescues CD8 T cells with
2024年12月16日 · Our findings show that CD24-Fc treatment significantly reduced inflammation and immune hyperactivation in vivo when combined with cART. CD24-Fc mediated resolution of inflammation was associated with improved recovery of CD4 T cells, reduced immune activation, restored central memory T cells and reversal of immune cell exhaustion phenotype.