The protein encoded by this gene is a member of the TNF-receptor superfamily. [11] This receptor is required for generation and long-term maintenance of T cell immunity . It binds to ligand CD70 , and plays a key role in regulating B-cell activation and immunoglobulin synthesis.

2024年12月24日 · CD27 (CD27 Molecule) is a Protein Coding gene. Diseases associated with CD27 include Lymphoproliferative Syndrome 2 and Combined T Cell And B Cell Immunodeficiency. Among its related pathways are Akt Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions.

2025年2月8日 · The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis.

缔码生物目前已成功完成CD27功能抗原制备，CD27参照抗体（Varlilumab biosimilar）制备，以及CD27单克隆抗体分子。 而 CD27-mAb B细胞种子库 ，能够快速筛选更多差异化分子，极大节约您的研发周期。

2025年2月8日 · CD27 is required for protective lytic EBV antigen-specific CD8+ T-cell expansion. Structural delineation and phase-dependent activation of the costimulatory CD27:CD70 complex. CD27 enhances the killing effect of CAR T cells targeting trophoblast cell surface antigen 2 in the treatment of solid tumors.

CD27 deficiency is a rare primary immune deficiency which affects T cells, B cells and NK cells and is associated with hypogammaglobulinemia. Clinical presentation varies from asymptomatic disease to life-threatening Epstein Barr Virus (EBV)-driven complications including malignancy.

CD27 expression is upregulated in a subset of hematopoietic cluster cells, and CD27 marks hematopoietic stem cells (HSC), type II pre-HSCs, and progenitors with lymphoid potential within the cluster cells.

2009年11月24日 · The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells (PubMed:28011863). Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory ...

2013年3月19日 · The CD27 gene was studied because flow cytometric analysis during diagnostic work-up showed absence of CD27 on all patient lymphocytes. CD27 is recognized as a marker for memory B cells and is considered of diagnostic value in patients who have decreased numbers of switched memory B cells.

Background: CD27 is an immunological checkpoint gene, plays a critical function inInhibition or activation of cancer immunity. The CD27/CD27L axis is its pathway of action. Therefore, our goal was to examine the predictive role of CD27 in the ...