Complement receptor type 1 (CR1) also known as C3b/C4b receptor or CD35 (cluster of differentiation 35) is a protein that in humans is encoded by the CR1 gene. [3][4] This gene is a member of the regulators of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1.

Complement receptors CD21 and CD35, which recognize activated products of C3 and C4, are predominantly expressed on B cells and follicular dendritic cells (FDCs) in the mouse. In this review, we focus on the role of FDC-expressed CD21 and CD35 in humoral immunity.

2024年4月15日 · CD35是一种表达于红细胞和免疫细胞表面的I型膜糖蛋白，是补体系统经典途径、凝集素途径和替代途径的中枢调节因子，它是C3b/C4b补体肽的受体，它能够结合补体的C4b和C3b片段，在吞噬细胞上发挥作用，促进这些细胞摄入激活补体的颗粒。

2024年12月24日 · CR1 (Complement C3b/C4b Receptor 1 (Knops Blood Group)) is a Protein Coding gene. Diseases associated with CR1 include Malaria and Follicular Dendritic Cell Sarcoma. Among its related pathways are Complement cascade …

1997年9月1日 · CR1 (CD35) is a single-chain, integral membrane glycoprotein that has been recognized as the major cellular receptor for C4b and C3b (Fearon 1980). The extracellular domain of the protein is comprised of SCR, which are characteristic of C3/C4 binding proteins (reviewed in Hourcade et al. 1989 ).

2019年11月21日 · Complement receptor 1 (CR1, CD35), which is responsible for the Knops blood group on erythrocytes (York and McCoy antigens), is also expressed by antigen-presenting cells. This regulates the complement system by removing opsonized antigens, blocking the final steps of the complement cascade.

Our functional studies show that after clustering CR1 both by its natural ligand and To5 mAb, the inhibitory function of CD35 is maintained in RA patients, despite its significantly reduced expression compared with healthy individuals.

According to receiver operating characteristic (ROC) analysis, a cutoff value of 7.256 (sensitivity: 90.0%, specificity: 93.7%) was determined for the NCD35/NCD64 ratio. This study shows that NCD35/NCD64 is helpful in the differential diagnosis of acute viral …

2002年3月22日 · Complement receptor type 1 (CR1 or CD35) is a multiple modular protein that mediates the immune adherence phenomenon, a fundamental event for destroying microbes and initiating an immunological response. It fulfills this role …

2013年5月1日 · In the present study, we aimed to perform quantitative analysis of membrane-bound complement regulators, CR1 (CD35), MCP (CD46), DAF (CD55), and MIRL (CD59), on peripheral blood neutrophils, monocytes, and lymphocytes from healthy controls (n = 36) and febrile patients diagnosed with either bacterial (n = 21) or viral (n = 26) infections.