2024年12月24日 · CD40LG (CD40 Ligand) is a Protein Coding gene. Diseases associated with CD40LG include Immunodeficiency With Hyper-Igm, Type 1 and Cd40 Ligand Deficiency. Among its related pathways are MIF Mediated Glucocorticoid Regulation and ERK Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and …

CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells [5] and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type.

CD40是一种48kda大小的Ⅰ型跨膜蛋白，是连接固有免疫和适应性免疫的重要免疫细胞通讯介质。 CD40存在于血小板、B细胞和髓系细胞，但也存在于非造血细胞，如内皮细胞、成纤维细胞、平滑肌细胞甚至某些类型的肿瘤细胞。 CD40的同源配体是CD154（TNFSF5/CD40L），一种39kda的II型跨膜蛋白。 CD40L的表达通常可诱导并局限于造血系统的细胞，如血小板、粒细胞、活化T细胞、活化B细胞和活化自然杀伤细胞（NK）细胞，但内皮细胞和平滑肌细胞也有弱表达。 …

大鼠 Rat Cd40lg 靶点分子功能（预测） Enables CD40 receptor binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of MHC class II biosynthetic process; and positive regulation of cytokine production.

The CD40LG gene provides instructions for making a protein called CD40 ligand, which is found on the surface of immune system cells known as T cells. Learn about this gene and related health conditions.

CD40 配体 (CD40LG/CD154/TNFSF5)是CD40的天然三聚体配体，是一种39kDa的II型膜糖蛋白，其在多种细胞类型上表达，包括活化的CD4+T细胞、活化的B细胞、记忆CD8+T细胞、激活的自然杀伤细胞、粒细胞、内皮细胞、平滑肌细胞、巨噬细胞和活化血小板。 CD40是在各种免疫细胞（如B细胞、树突细胞和巨噬细胞）上表达的受体蛋白。 CD40L可与CD40相互作用，触发这些免疫细胞的过度刺激，导致免疫反应级联和介导炎症的过度生产，从而导致很多自身免疫性疾病 …

6 天之前 · Title: Respiratory infections in X-linked hyper-IgM syndrome with CD40LG mutation: a case series of seven children in China. Termination of CD40L co-stimulation promotes human B cell differentiation into antibody-secreting cells.

2025年2月8日 · Data show that reciprocal translocation caused disruption of CD40LG, resulting in defective CD40L expression with a skewed X-inactivation pattern in T cells leading to the HIGM1 phenotype. Patients with unstable angina show an enhanced coagulation activation and an upregulation of CD40L on platelets.

该基因编码的蛋白质在 T 细胞表面表达。 它通过结合 B 细胞表面的 CD40 来调节 B 细胞功能。 该基因的缺陷导致无法进行免疫球蛋白类别转换，并与高 IgM 综合征有关。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface.

CD40 Ligand (CD40L; CD154; TRAP) belongs to the tumor necrosis factor (TNF) family, is the ligand for CD40/TNFRSF5, specifically expressed on activated CD4+ T-lymphocytes [1]. CD40L is a type II transmembrane protein on B cells triggers important signals for B cell differentiation, maturation, and apoptosis [2].