CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells [5] and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen …

Dec 24, 2024 · CD40LG (CD40 Ligand) is a Protein Coding gene. Diseases associated with CD40LG include Immunodeficiency With Hyper-Igm, Type 1 and Cd40 Ligand Deficiency . …

The CD40LG gene provides instructions for making a protein called CD40 ligand, which is found on the surface of immune system cells known as T cells. Learn about this gene and related …

CD40 binds its ligand CD40L, which is transiently expressed on T cells and other non-immune cells under inflammatory conditions. A wide spectrum of molecular and cellular processes is …

Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding of CD154 (CD40L) on T H cells to CD40 …

Mar 26, 2025 · Title: Respiratory infections in X-linked hyper-IgM syndrome with CD40LG mutation: a case series of seven children in China. Termination of CD40L co-stimulation …

The X-linked gene CD40LG encodes CD40L, a T-cell coactivation receptor expressed under transcriptional control of nuclear factor of activated T-cells (NFAT). 5 CD40L-deficient patients …

Feb 8, 2025 · A novel CD40LG deletion causes the hyper-IgM syndrome with normal CD40L expression in a 6-month-old child; Report targeting and liposomal drug delivery of …

Gauchat et al. (1993) cloned the cDNA for human CD40 ligand (CD40LG) from a CD4-positive T-cell clone. The cDNA predicts a type II membrane protein of 261 amino acids. Seyama et al. …

Clinical resource with information about CD40LG, Hyper-IgM syndrome type 1, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, …