CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene. [5] CD46 is an inhibitory complement receptor .

2024年12月24日 · CD46 (CD46 Molecule) is a Protein Coding gene. Diseases associated with CD46 include Hemolytic Uremic Syndrome, Atypical 2 and Genetic Atypical Hemolytic-Uremic Syndrome. Among its related pathways are Complement cascade and Immune response Lectin induced complement pathway.

2019年11月29日 · CD46为一单链跨膜糖蛋白，其染色体定位于人类1号染色体短臂的32号区，分子量为45-70kDa，又命名为gp45-70，属于补体活化调节蛋白因子家族。CD46的N端由四个补体控制蛋白（CCP）组成，后面是通过选择性剪接产生的O-高度糖基化区域，并包含B和/或C异构体。

Membrane cofactor protein (MCP; CD46) is a type one transmembrane complement regulatory protein expressed by almost every cell type (with the noteworthy exception of erythrocytes) (reviewed in Refs. [6, 7, 8]). It binds the two key activation fragments, C3b and C4b, that covalently deposit on self-tissue.

In the last 10 years, the human cell-surface molecule, CD46, has evolved from 'just another complement regulator' to a receptor for a striking array of pathogens. CD46 not only protects cells from complement-mediated attack and facilitates infection by a large number of pathogens, but also exerts co …

2015年6月10日 · Membrane cofactor protein (MCP; CD46) is an ubiquitously expressed complement regulatory protein that protects host cells from injury by complement. This type-I membrane glycoprotein serves as a cofactor for the serine protease factor I to mediate inactivation of C3b and C4b deposited on host cells.

cd46 分子： 该基因编码的蛋白质是 i 型膜蛋白，是补体系统的调节部分。 编码的蛋白质具有辅助因子活性，可通过血清因子 I 使补体成分 C3b 和 C4b 失活，从而保护宿主细胞免受补体损伤。

In particular, the complement regulator CD46 emerges as a key sensor of immune activation and a vital modulator of adaptive immunity. In this review, we summarize the current knowledge of CD46-mediated signalling events and their functional consequences on immune-competent cells with a specific focus on those in CD4(+) T cells.

2024年11月18日 · cd46是一种补体激活调节剂，属于rca蛋白质家族。 它通过介导C3b和C4b裂解辅助因子，成为先天免疫系统中经典和选择性补体激活级联反应的关键调节因子。

CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in preventing complement deposition ...