CD6 (C luster of D ifferentiation 6) is a human protein encoded by the CD6 gene. [5][6] This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule.

2024年12月24日 · CD6 (CD6 Molecule) is a Protein Coding gene. Diseases associated with CD6 include Multiple Sclerosis and Graft-Versus-Host Disease. Gene Ontology (GO) annotations related to this gene include scavenger receptor activity. An …

2021年12月27日 · cd6是一种1型跨膜糖蛋白，并作为t细胞抗原受体信号通路的一部分发挥作用。 CD6在细胞外部分包含三个富含半胱氨酸的清道夫受体（SRCR）结构域，该结构域也高度糖基化，具有七个推定的N-糖基化位点。

2018年3月23日 · Although CD6 was one of the earliest “CD antigens” to be described, it is only recently that attention has refocused on the potential for CD6 as a treatment target in immune-mediated diseases....

设立分化簇 (CD) 命名系统的目的是对白细胞表面抗原进行分类。 最初，表面抗原是根据与它们结合的对应单克隆抗体进行命名。 随着各实验室逐渐发现抗原常能刺激产生多种单克隆抗体，因此需要采用一种统一的命名系统。 1982 年于巴黎举行的第 1 届国际人类白细胞分化抗原专题讨论会 (HLDA) 上通过了目前使用的命名系统。 根据该命名系统，已经充分表征的抗原将会分配数字（例如，CD1、CD2 等），而对于仅有一种单克隆抗体可以识别的抗原分子，则分配临时名 …

CD6 has been exploited as a drug target as its expression is restricted, primarily to T cells, it has a well characterised cell surface ligand, CD166 and regulates T cell activation through a long cytoplasmic tail. CD6 can affect both the initiation and maintenance of T …

2023年12月21日 · CD6 （cluster of differentiation 6，分化簇6）是一种细胞表面蛋白质，由人类基因 CD6 编码 [6]，主要在 T淋巴细胞 等 免疫细胞 上表达 [7]。 ^ 與CD6相關的疾病；在維基數據上查看/編輯參考. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

2024年9月13日 · CD6蛋白是一种重要的免疫系统受体，主要在T细胞表面表达。 它在免疫细胞的激活、增殖、分化以及免疫调节中发挥关键. 作用。 CD6不仅在免疫应答中扮演重要角色，还涉及细胞信号传导的复杂网络。 本文将详细探讨CD6蛋白的结构与功能、 其在细胞信号传导中的作用机制以及其生物学意义。 1. CD6蛋白的结构与功能. 结构特征：CD6是一种跨膜糖蛋白，属于免疫球蛋白超家族。 其结构包括多个免疫球蛋白样结构域和一个细胞内的信号转. 导区。 CD6的外 …

2021年3月8日 · The combined capability of an anti-CD6 monoclonal antibody to control autoimmunity through effects on CD4+ lymphocyte differentiation while enhancing killing of cancer cells through distinct effects on CD8+ and NK cells opens a potential new approach to cancer immunotherapy that would suppress rather than instigate autoimmunity.

CD6 is a lymphocyte receptor selectively expressed on most T cells and some B cells. CD6 is involved in cell-to-cell contacts and modulation of adaptive immune responses. CD6 interacting partners include CD166/ALCAM, CD318 and certain PAMPS and DAMPS. CD6 is implicated in the pathogenesis of a variety of immune-mediated conditions.