
CD6 as a Cell Surface Receptor and As a Target for Regulating ... - PubMed
The effective mode of action of clinical monoclonal antibodies (mAbs) that recognise cell surface receptors including CD6 is commonly cytotoxic depletion of cells. It is not clear how current …
The role of CD6 in autoimmune diseases - Nature
2018年3月23日 · Although CD6 was one of the earliest “CD antigens” to be described, it is only recently that attention has refocused on the potential for CD6 as a treatment target in immune …
Clinical and experimental evidence for targeting CD6 in immune …
2018年5月1日 · CD6 is a lymphocyte receptor selectively expressed on most T cells and some B cells. CD6 is involved in cell-to-cell contacts and modulation of adaptive immune responses. …
CD6 in Human Disease - MDPI
2025年2月13日 · CD6 plays critical roles in lymphocyte activation, proliferation, and adhesion to antigen-presenting, epithelial, and cancer cells. CD6 is a risk gene for multiple autoimmune …
CD6, a Rheostat-Type Signalosome That Tunes T Cell Activation
2018年12月17日 · CD6 favors thymocyte differentiation and maturation and is required for selection of thymocytes with high-avidity TCRs. CD6 is expressed at all stages of thymocyte …
CD6 - an overview | ScienceDirect Topics
CD6 is a signal-transducing receptor almost exclusively expressed by lymphocytes. CD6 was one of the first discovered lymphocyte surface receptors in the early 1980's, thanks to the …
Structures of CD6 and Its Ligand CD166 Give Insight into Their ...
2015年8月4日 · We have solved the X-ray crystal structures of the three SRCR domains of CD6 and two N-terminal domains of CD166. This first structure of consecutive SRCR domains …
CD6 in Human Disease - PubMed
2025年2月13日 · CD6 is a risk gene for multiple autoimmune diseases, possibly related to its numerous roles in regulating CD4+T-cell responses. Additionally, CD6 is a potential target for …
Failure of a T cell regulator: CD6 contributes to the ... - Nature
2018年7月12日 · The scavenger-like lymphocyte receptor CD6 is a regulator of T cell functions, and is associated with autoimmune diseases. However, the specific contribution of CD6 to …
CD6 monoclonal antibodies differ in epitope, kinetics and …
CD6 monoclonal antibodies (mAbs) specific for the membrane distal domain (domain 1) perturb CD6 function including itolizumab (Alzumab™), which has reached the clinic for treatment of …
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