CD7 (C luster of D ifferentiation 7) is a protein that in humans is encoded by the CD7 gene. [5] This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells.

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2024年12月24日 · CD7 (CD7 Molecule) is a Protein Coding gene. Diseases associated with CD7 include Mycosis Fungoides and Lymphoblastic Lymphoma. Among its related pathways is Innate Lymphoid Cells Differentiation. Gene Ontology (GO) annotations related to this gene include signaling receptor activity.

CD7 is a single-domain Ig superfamily molecule expressed on human T and NK cells, as well as on cells in the early stages of T, B, and myeloid cell differentiation. CD7 is highly expressed on malignant immature T cells and is generally absent on malignant mature T cells, such as CD4+ Sezary leukemia …

2003年3月1日 · CD7 identifies three populations of CD8 T cells: CD7 high (CD7(high)), low (CD7(low)), and negative (CD7(neg)) that translate into subsets with distinct functional properties. The CD7(high) subset contains naive and memory cells and the CD7(low) and CD7(neg) subsets contain effector cells.

CD7, also known as GP40, is a membrane-expressed protein that belongs to the immunoglobulin superfamily. CD7 expression was detected in T cells and subsequently shown to also be present on natural killer (NK) cells [, , ], indicating a role for CD7 in the immune system.

CD7 is a transmembrane glycoprotein and a member of the immunoglobulin supergene family. You might find these chapters and articles relevant to this topic.

2024年6月19日 · CD7, also known as GP40, is a 40 kDa glycoprotein encoded by the CD7 gene located on chromosome 17. It belongs to the immunoglobulin superfamily and contains a single extracellular immunoglobulin-like domain, a transmembrane region, and a short cytoplasmic tail.

Interestingly, under physiological and different pathological conditions, the loss of CD7 antigen occurred in the subset of CD4 + memory T cells. Various functions have been proposed for CD7, including its role in the activation and intercellular adhesiveness of T cells.

2017年7月20日 · CD7 is a transmembrane protein highly expressed in acute T-cell leukemia (T-ALL) and in a subset of peripheral T-cell lymphomas. Normal expression of CD7 is largely confined to T cells and natural killer (NK) cells, reducing the risk of off-target-organ toxicity.