CDC20 is a protein related to the beta subunit of heterotrimeric G proteins. Near its C-terminus it contains seven WD40 repeats, which are multiple short, structural motifs of around 40 amino acids that often play a role in binding with larger protein complexes. In the case of CDC20, they arrange into a seven-bladed beta propeller.

2024年12月24日 · CDC20 (Cell Division Cycle 20) is a Protein Coding gene. Diseases associated with CDC20 include Oocyte/Zygote/Embryo Maturation Arrest 14 and Infertility. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and EML4 and NUDC in mitotic spindle formation.

2017年9月3日 · 摘要: 细胞分裂后期促进复合物（APC）具有调节细胞周期进展的作用，经细胞分裂周期蛋白20（Cdc20）或Cdc20同系物1（Cdh1）活化后形成两种不同的E3泛素连接酶复合物APC Cdc20 或APC Cdh1。 Cdc20为促癌因子，Cdh1为抑癌因子，在肿瘤的发生及发展中发挥不同的作用。 越来越多的研究表明，Cdc20对肿瘤的发生起促进作用，很多肿瘤中存在Cdc20的高表达。 目前Cdc20抑制剂除了apcin外，大部分为非特异性抑制剂，不仅阻断Cdc20与APC的结 …

Cell-division cycle protein 20 homologue (Cdc20) has important functions in chromosome segregation and mitotic exit. Cdc20 is the target of the spindle assembly checkpoint (SAC) and a key cofactor of the anaphase-promoting complex or cyclosome (APC/C) E3 ubiquitin ligase, thus regulating APC/C ubiqu …

2024年2月9日 · Cdc20 is a key subunit of the MCC 2, 3, which is produced at unattached kinetochores by the SAC signaling pathway. The MCC binds and inhibits the APC/C E3 ligase to delay the transition from...

2022年4月30日 · More recently, novel CDC20 functions have been demonstrated or suggested, including the regulation of apoptosis and stemness properties and a correlation with immune cell infiltration. Here, we here summarize and discuss the role of CDC20 inside and outside mitosis, starting from its network of interacting proteins.

2013年7月20日 · 摘要:cdc20是细胞周期相关蛋白之一.在细胞分裂周期中,cdc20 是纺锤体组装检查点的靶向物和有丝分 裂后期促进复合体的正调控因子,在引导细胞周期中某些蛋白质的

CDC20 appears to act as a regulatory protein interacting with several Other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation.

In this review, we will discuss the physiological role of Cdc20 and its downstream substrates in vitro and in the transgenic mouse model reminiscent of the pathogenesis of human cancers. Furthermore, we summarize recent findings to indicate that Cdc20 may represent a promising therapeutic target, thus development of Cdc20 inhibitors could be ...

2017年3月1日 · Cdc20 is the target of the spindle assembly checkpoint (SAC) and a key cofactor of the anaphase-promoting complex or cyclosome (APC/C) E3 ubiquitin ligase, thus regulating APC/C ubiquitin activity on specific substrates for their subsequent degradation by …