CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1. [5] [6] [7] This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes the …

2024年12月24日 · CDC34 (Cell Division Cycle 34, Ubiqiutin Conjugating Enzyme) is a Protein Coding gene. Diseases associated with CDC34 include Three M Syndrome 1. Among its …

2019年7月24日 · Cdc34 is an E2 that plays a key role in regulating cell cycle progression and requires unique structural elements to function. The molecular basis by which Cdc34 engages …

2025年2月9日 · Cdc34 is a functional target of let-7 and that let-7 induces down-regulation of Cdc34, stabilization of the Wee1 kinase, and an increased fraction of cells in G(2)/M in primary …

Ubiquitous expression in testis (RPKM 23.4), placenta (RPKM 14.2) and 25 other tissues. 该基因编码的蛋白质是泛素结合酶家族的成员。 泛素结合酶催化泛素与其他蛋白质的共价连接。 这 …

Our results showed that CDC34 was overexpressed and inversely associated with clinical outcome of the patients, and promoted NSCLC cell proliferation in vitro and in vivo. CDC34 …

2019年11月9日 · 研究者Katelyn Williams表示，我们重点对Cdc34进行研究是因为其具有一定的临床相关性，Cdc34是很多生物学过程和癌症异常功能的关键调节子；同时Cdc34 ...

CDC34 competes with c-Cbl to bind Y1045 to inhibit polyubiquitination and degradation of EGFR. In EGFR-L858R and EGFR-T790M/Del (exon 19)-driven lung tumor growth in mouse models, …

Immunohistochemistry and cellular fractionation reveals a heterogeneous CDC34 expression pattern including cells containing primarily cytoplasmic or nuclear protein. Thus, a feature of …

2017年6月13日 · Silencing of TbCDC34 in BSF cells resulted in a block in cytokinesis and caused rapid clearance of parasites from infected mice. We also show that TbCDC34 is able to …