Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene. [5] [6] The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication.

细胞分裂周期蛋白6（CDC6）在DNA复制过程中发挥重要作用。作为前复制复合物（pre-RC）中的核心成员，如果CDC6发生突变或缺失，pre-RC将无法组装，DNA复制也会受到抑制。由于CDC6在细胞周期进程中扮演着关键角色，…

2024年12月24日 · CDC6 (Cell Division Cycle 6) is a Protein Coding gene. Diseases associated with CDC6 include Meier-Gorlin Syndrome 5 and Meier-Gorlin Syndrome 1. Among its related pathways are Activation of the pre-replicative complex and CDK-mediated phosphorylation and removal of Cdc6.

用生长促进因子刺激细胞导致cyclinD (包括D1、D2和D3三种同源蛋白）上调，其激活CDK4和CDK6。 在经典的细胞周期模型中，CyclinD-CDK4/6复合物与cyclinE（包括E1和E2两种同源蛋白）及其相关激酶（主要是CDK2，但也有CDK1和CDK3）可以磷酸化细胞周期负调节因子RB1以及RB1同源蛋白RBL1/2（kegg 图中称为p107,130）。 非磷酸化的RB1对转录因子E2F1/2/3有转录抑制作用。 而磷酸化的RB1与E2F1/2/3脱离，从而释放E2F1/2/3的转录活性。 然后转录因 …

2007年11月28日 · Cell division cycle 6 (CDC6) is an essential regulator of DNA replication in eukaryotic cells. Its best-characterized function is the assembly of prereplicative complexes at origins of replication during the G 1 phase of the cell division cycle.

2021年6月23日 · Here we report the cryo-EM structure at 3.3 Å resolution of the yeast ORC–Cdc6 bound to an 85-bp ARS1 origin DNA. The structure reveals that Cdc6 contributes to origin DNA recognition via its...

周期蛋白6 (CDC6)是组成前复制复合物 (Pre-RC)的主要蛋白之一,控制细胞从G1期进入S期,同时也参与激活和维持有丝分裂S-M期检测点机制.最近的研究发现其也具有原癌基因的特性,并在人多种肿瘤细胞中存在高表达,对肿瘤发生发展起重要作用.CDC6致癌机制可能与INK4/ARF连结物信号途径和 (或)某些替代机制有关。 引用本文: 张佳华, 黄士昂. 周期蛋白6在DNA复制、细胞周期检测点和肿瘤发生发展中的作用 [J] . 国际肿瘤学杂志,2009,36 ( 06 ): 411-414. DOI: …

2020年10月5日 · Cell division cycle 6 (Cdc6) plays key roles in regulating DNA replication, and activation and maintenance of cell cycle check points. In addition, Cdc6 exerts oncogenic...

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase.

The CDC6 gene provides instructions for making a protein that is important in the copying of a cell's DNA before the cell divides (a process known as DNA replication). The protein produced from this gene, called cell division cycle 6 or CDC6, is one of a group of proteins known as the pre-replication complex.