CDK11, a splicing-associated kinase regulating gene expression
2024年9月7日 · Cyclin-dependent kinase (CDK)11 is a little-studied, essential kinase in metazoans, regulating gene expression and cellular proliferation. OTS964 is a potent and selective CDK11 inhibitor. Recent research has revealed a direct role of CDK11 in spliceosome activation and constitutive pre-mRNA splicing.
CDK（周期蛋白依赖性激酶）_百度百科
CDK，即周期蛋白依赖性激酶(cyclin-dependent kinases)是与细胞周期进程相对应的一套Ser/Thr激酶系统。 各种CDK沿细胞周期时相交替活化，磷酸化相应底物，使细胞周期事件有条不紊地进行下去。
CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1
2022年9月14日 · We demonstrate a central role of CDK11 in spliceosome assembly and splicing regulation and characterize OTS964 as a highly selective CDK11 inhibitor that suppresses spliceosome activation and...
浅谈细胞增殖的调节因子——细胞周期蛋白 (Cyclin) - 丁香园论坛
2024年11月19日 · Cyclin是一类能够周期性地表达和降解的蛋白质，通过与周期蛋白依赖性激酶（CDKs）组成复合物，在细胞周期的不同阶段起着关键的调控作用。 Cyclin蛋白家族包含多个不同亚型的蛋白，如Cyclin A、Cyclin B、Cyclin D、Cyclin E等，每种Cyclin在特定的细胞周期阶段表达量最高，并与特定的CDK形成复合物，共同调控细胞周期的进程。 表达于S期和G2期，与CDK2结合促进DNA复制。 在M期与CDK1结合，参与调控有丝分裂过程中的关键事件，如细 …
CDK11, a splicing-associated kinase regulating gene expression
Recent work has showed that cyclin-dependent kinase (CDK)11 regulates spliceosome activation via the phosphorylation of SF3B1, a core spliceosome component. Thus, CDK11 arises as a major coordinator of gene expression in metazoans …
热门靶点- 细胞周期依赖性激酶CDKs介绍 - 知乎 - 知乎专栏
cdk家族蛋白在细胞周期中调控关键的检查点，是充分被验证可用于各种疾病治疗的靶点。主要的药物发现集中在经典的atp竞争性抑制剂，而新技术的出现也推动了非经典的cdk抑制剂的研究，如变构位点抑制剂、共价抑制剂和非atp竞争的多肽模拟物。
Synthesis and Structure–Activity relationships of cyclin-dependent ...
2022年8月5日 · CDK11 is an understudied CDK with roles in transcription and splicing, cell cycle regulation, neuronal function, and apoptosis. In this study, we describe a medicinal chemistry campaign to identify a CDK11 inhibitor.
The Emerging Picture of CDK11: Genetic, Functional and
Cyclin-dependent kinase 11 is a relatively neglected member of the transcriptional CDKs subfamily, despite possibly being the most versatile CDK in this group. Different CDK11 variants are known to play essential roles in major cellular processes as mRNA transcription (CDK11p110), mitosis (CDK11p58) …
CDK11 requires a critical activator SAP30BP to regulate pre-mRNA ...
2023年12月11日 · CDK11 is an emerging druggable target for cancer therapy due to its prevalent roles in phosphorylating critical transcription and splicing factors and in facilitating cell cycle progression in cancer cells. Like other cyclin-dependent kinases, CDK11 requires its cognate cyclin, cyclin L1 or cyclin L2, for activation.
周期蛋白依赖性激酶 - 维基百科，自由的百科全书
CDK抑制因子 （ 英语 ： Cyclin-dependent kinase inhibitor protein ） （CKI）是一类与周期素-CDK复合物相互作用来阻断其激酶活性的蛋白，常见于G1期或对DNA损伤及环境信号的响应 [1] 。