CDKAL1 (Cdk5 regulatory associated protein 1-like 1) is a gene in the methylthiotransferase family. The complete physiological function and implications of this have not been fully determined. CDKAL1 is known to code for CDK5, a regulatory subunit-associated protein 1. [5]

2024年12月24日 · CDKAL1 (CDK5 Regulatory Subunit Associated Protein 1 Like 1) is a Protein Coding gene. Diseases associated with CDKAL1 include Type 2 Diabetes Mellitus and Maturity-Onset Diabetes Of The Young. Among its related pathways are tRNA processing and Processing of Capped Intron-Containing Pre-mRNA.

cdkal1 (cdk5调节亚基相关蛋白1类似物1)位点与民族、种族的关联性，为本地区少数民族易感人群的 筛选和疾病分子分型提供基础。 选取近 5 年相关文献分析 CDKAL1 基因及不同基因位点在 T2DM 不同人群

Cdkal1 is an Endoplasmic Reticulum (ER) membrane bound protein and member of methylthiotransferase (MTTase) family of the radical S-adenosylmethionine superfamily, having distinct role in catalyzing the conversion of C-H to C-SCH 3 (addition of thiomethyl group).

Cdkal1 is a gene most strongly expressed in tissues with high mitochondrial content. Cdkal1 is required for normal mitochondrial morphology and function. Deletion of Cdkal1 in adipose tissue impairs the thermogenic response to a cold challenge. Cdkal1 interacts with ANT1, a mitochondrial ATP/ADP transporter.

Variants within CDKAL1 are strongly linked to an increased risk of developing type 2 diabetes and obesity. Investigations in mouse models have focused on the function of Cdkal1 as a tRNA Lys modifier and downstream effects of Cdkal1 loss on pro-insulin translational fidelity in …

2020年1月15日 · We found that cellular iron deficiency impairs the function of Cdk5-regulatory subunit-associated protein 1-like 1 (Cdkal1), a radical S -adenosylmethionine (SAM) enzyme that contains 4Fe–4S...

2022年1月13日 · Cdkal1 is an Endoplasmic Reticulum (ER) membrane bound protein and member of methylthiotransferase (MTTase) family of the radical S-adenosylmethionine superfamily, having distinct role in catalyzing the conversion of C-H to C-SCH 3 (addition of thiomethyl group).

2022年1月13日 · Recent studies have shown that Cdkal1 has an intrinsic thiomethyl transferase activity, which is essential for proper posttranslational processing of pre-proinsulin to produce mature insulin. Moreover, Cdkal1 has also been claimed as an endogenous inhibitor of cdk5, which prevents the cdk5-induced interruption in insulin synthesis through PDX1 ...

2012年12月7日 · We show that CDKAL1 is a novel member of the tail-anchored protein family and exploits the TCR40/Get3-assisted pathway for insertion of its C-terminal transmembrane domain into the endoplasmic reticulum.