NK细胞的单细胞层面细分亚群 - 知乎 - 知乎专栏
自然杀伤细胞（Natural Killer cells，简称NK细胞）是一类免疫细胞，主要参与体内的免疫应答和抗肿瘤免疫。 NK细胞的分类可以基于其表面标志物、功能、发育阶段以及组织分布等方面进行。
NK cell CD16 surface expression and function is regulated by a ...
Activated NK cells loose CD16 (FcRγIII) and CD62L through a metalloprotease called ADAM17. Inhibition of ADAM17 enhances CD16 mediated NK cell function by preserving CD16 on the NK cell surface to enhance ADCC.
CD56bright natural killer (NK) cells: an important NK cell subset
Human natural killer (NK) cells can be subdivided into different populations based on the relative expression of the surface markers CD16 and CD56. The two major subsets are CD56bright CD16dim/− and CD56dim CD16+, respectively. In this review, we ...
NK cell development, homeostasis and function: parallels with …
2011年8月26日 · In this Review, we highlight the many stages that an NK cell progresses through during its remarkable lifetime, discussing similarities and differences with its close relative, the cytotoxic CD8...
Human CD56 bright NK Cells: An Update - American Association …
2016年4月1日 · In this article, we summarize recent studies about CD56 bright NK cells in health and disease and briefly discuss the current controversies surrounding them. Natural killer cells are cytotoxic type 1 innate lymphoid cells that are important in anti-infectious and anticancer defense.
Distinctive CD56dim NK subset profiles and increased NKG2D
2024年2月15日 · We analyzed cryopreserved PMBC samples using a 10-color flow cytometry panel to evaluate NK cell subpopulations in 31 individuals with sporadic PD and 27 HC participants. Here we identified...
CD56brightCD16+ NK Cells: A Functional Intermediate Stage of NK Cell …
2011年6月15日 · Human NK cells are identified by the CD3 − CD56 + phenotype. Different NK cell subpopulations are determined according to the presence and density of CD56 and CD16 (FcγRIII) surface molecules. Low-density CD56 (CD56 dim) subsets constitute >90% of peripheral blood NK cells, which also express perforin and killer Ig-like receptors (KIR ...
CD57 defines a functionally distinct population of mature NK cells …
Natural killer (NK) cells are innate immune lymphocytes that express a heterogeneous repertoire of germline-encoded receptors and undergo a distinct pattern of maturation. CD57 is a marker of terminal differentiation on human CD8 + T cells.
Distinguishing Human Peripheral Blood NK Cells from CD56
2018年2月21日 · Natural killer (NK) cells are members of the innate lymphoid cells group 1 (ILC1s), which play a critical role in innate host defense against viruses and malignancies....
NK cell CD16 surface expression and function is regulated by a ... - PubMed
2013年5月2日 · The Fc receptor CD16 is present on essentially all CD56(dim) peripheral blood natural killer (NK) cells. Upon recognition of antibody-coated cells it delivers a potent signal to NK cells, which eliminate targets through direct killing and cytokine production. Here we investigated the regulation of CD16 surface expression after NK cell activation.