2023年5月30日 · CEA / CD66e is usually considered an epithelial marker with expression in various adenocarcinomas; in addition to immunostaining, CEA is a nonspecific serum biomarker that can be elevated in various malignancies

2024年12月11日 · Carcinoembryonic antigen (CEA) is a nonspecific serum biomarker that is elevated in many malignancies, including colorectal cancer, medullary thyroid cancer, breast cancer, and mucinous ovarian cancer.

Carcinoembryonic antigen (CEA) describes a set of highly-related glycoproteins involved in cell adhesion. CEA is normally produced in gastrointestinal tissue during fetal development, but the production stops before birth. Consequently, CEA is usually present at very low levels in the blood of healthy adults (about 2–4 ng/mL). [2]

A carcinoembryonic antigen (CEA) test measures a specific blood glycoprotein called CEA. It means a protein with a lot of sugars added to it by normal or cancerous cells. Scientists first discovered CEA in 1968 when they isolated extracts of liver metastasized by colorectal cancer and also from normal fetal digestive tract.

In the field of pathology, monoclonal and polyclonal CEA immunohistochemical stains serve as diagnostic tools. Polyclonal CEA staining reveals a canalicular pattern, which is a specific indicator of HCC. It allows for the precise and confident diagnosis of HCC, distinguishing it from other types of tumors.

CEA 是一种具有人类胚胎抗原特异性的酸性糖蛋白，于 1965 年由 Gold 和 Freedman首先从结肠癌和胚胎组织中提取的一种肿瘤相关抗原，随后在多种其他类型的肿瘤患者、有多年吸烟史的人群或有某些其他非恶性疾病患者的血液中均可检测到 CEA 的浓度升高。 其生理来源通常来源于胎儿的胚胎内胚层上皮，受胎儿致癌基因控制，常在出生后从血清中消失，然而，少量的 CEA 可能残留在结肠组织中，CEA及其相关基因（29个中其中18个正常表达）构成了人类的CEA家族， …

All tumors except 2 showed positive staining for CEA. The staining pattern was classifiable into 4 types: apical, cytoplasmic, basolateral and stromal, according to the predominant sites of staining. We found a significant positive correlation between …

2016年8月5日 · Carcinoembryonic antigen, abbreviated CEA, is set of glycoproteins present during fetal development and associated with the gastrointestinal tract. In pathology, they are associated with gastrointestinal tract tumours; however, may be seen in other tumours.

Polyclonal and many monoclonal antibodies identify antigens that are present on many of the glycoproteins within the CEA superfamily. 1 Newer monoclonal CEA antibody clones are available that react with epitopes found predominantly on the unique portion of the CEA glycoprotein, and therefore have significantly reduced background necrosis and ...

If you do not have electronic ordering capability, use an ARUP Immunohistochemistry Stain Form (#32978) with an ARUP client number. For additional technical details, contact ARUP Client Services at (800) 522-2787.