2024年12月24日 · CELF2 (CUGBP Elav-Like Family Member 2) is a Protein Coding gene. Diseases associated with CELF2 include Developmental And Epileptic Encephalopathy 97 and Non-Specific Early-Onset Epileptic Encephalopathy. Among its related pathways is Processing of Capped Intron-Containing Pre-mRNA.

2024年7月1日 · CELF2, previously known as mNapor, exhibits a temporal and spatial expression pattern that closely aligns with neuronal apoptosis, suggesting its involvement in central nervous system development by modulating apoptosis processes (Choi et al., 1999).

2025年2月9日 · RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery. CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction.

2019年9月10日 · CELF2 is a member of the CUG-BP, Elav-like family (CELF) of binding proteins. It binds preferentially to single-stranded UG and CUG-rich RNA elements and has been widely studied as a regulator of splicing in heart and skeletal muscle, neurons, and T cells (Dasgupta and Ladd, 2012; Gazzara et al., 2017; Ladd et al., 2001).

2024年3月21日 · As a key member of RBPs, ELAV-like family protein 2 (CELF2) has been shown to regulate RNA splicing and embryonic hematopoietic development and was frequently seen dysregulated in acute myeloid...

CELF/BRUNOL 蛋白家族的成员包含两个 N 端 RNA 识别基序 (RRM) 结构域、一个 C 端 RRM 结构域，以及第二个和第三个 RRM 结构域之间的 160-230 aa 的不同片段。 该蛋白家族的成员调节 pre-mRNA 可变剪接，也可能参与 mRNA 编辑和翻译。 可变剪接导致编码不同异构体的多个转录变体。 [RefSeq 提供，2008 年 7 月]

2020年10月22日 · Although the overexpression of both CELF1 and CELF2 enhanced exon 3 skipping, only CELF2 reduced the expression of full-length TREM2 protein. Notably, the TREM2 ortholog in the green monkey,...

2024年11月2日 · Here we demonstrate that CELF2, a splicing regulator and a GWAS-identified risk factor for Alzheimer's disease, binds to mRNAs associated with neurodegenerative diseases, with a specific interaction observed in the intron adjacent to exon 10 on Tau mRNA.

2025年1月5日 · 本文将详细介绍CELF2基因的功能、作用机制、信号通路及其与疾病的关系，帮助读者全面了解这一重要的RNA结合蛋白基因。 CELF2基因：RNA世界的守护者 基因概述 CELF2，全称CUGBP Elav-like family member 2，位于人类染色体10p14位置。

CUGBP Elav-like family member 2(CELF2) plays crucial roles in the development and activation of T cell. However, the impacts of CELF2 on tumour-infiltrating immune cells (TIICs) and clinical outcomes of tumours remain unclear. In this study, we found that elevated CELF2 expression was markedly corre …