1990年6月29日 · In T brucei, a significant sequence complementarity exists between the spliced leader RNA Cell 1160 and U2 RNA, which overlaps the putative U2 RNA branchpoint recognition region.

By using an ER-phagy reporter and genome-wide CRISPRi screening, we identified 200 high-confi-dence human ER-phagy factors. Two pathways were unexpectedly required for ER-phagy. First, reduced mitochondrial metabolism represses ER-phagy, which is opposite of general autophagy and is independent of AMPK.

Ovation® pipettes have a unique and patented ergonomic design. They are the only pipettes that fully address the issues of posture, repetition, and force to significantly reduce strain and pain that occur from pipetting, while always providing superior accuracy and precision.

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens. Pan-cancer proteomic map of 949 human cell lines.

Pre-cool centrifuge to 4oC. Pre-cool all solutions and tubes on ice and work fast (do not process more than 4 samples in parallel). Use ice cold lysis buffer and keep lysates on ice.

Although a different (or cell type-dependent) degradation profile was obtained in OVCAR8 cells, where CDK4 and CDK6 were not degraded ( Figure S2), we decided to optimize TMX-1160 to achieve...

2019年11月14日 · Pediatric-onset colitis and inflammatory bowel disease (IBD) have significant effects on the growth of infants and children, but the etiopathogenesis underlying disease subtypes remains incompletely understood. Here, we report single-cell clustering, immune phenotyping, and risk gene analysis for ch …

PRO-1160: 一种CD70抑制剂、TOP1抑制剂药物，由ProfoundBio (Suzhou) Co., Ltd. (普方生物制药（苏州）有限公司)公司最早进行研发，目前全球最高研发状态为临床1/2期，作用机制: CD70抑制剂(CD70抗原抑制剂),TOP1抑制剂(DNA拓扑异构酶I抑制剂)，治疗领域: 肿瘤,免疫系统疾病 ...

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Aluminum & Steel Control Arm Assembly Cell Aluminum & Steel Control Arm Assembly Cell Roboterisierte Zelle für die Montage von Kugelgelenken und Buchsen an Querlenkern aus Aluminium und Stahl. Die Linie umfasst 3 elektrische Pressen für Buchsen, einen Rundtisch für die vollständige Montage von Kugelgelenken, Drehmomentkontrolle, DMC-Lasermarkierung