The human leukocyte antigen (HLA) system is a complex of genes on chromosome 6 in humans that encode cell-surface proteins responsible for regulation of the immune system. [1] The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals.

人類白細胞抗原（英語： Human leukocyte antigen ，缩写： HLA ），是編碼人类的主要组织相容性复合体（MHC）的基因。 其位于 6号染色体 的短臂上（6p21.31），包括一系列紧密连锁的 基因座 ，与人类的 免疫系统 功能密切相关。

人类白细胞抗原 （英语：human leukocyte antigen）- HLA是在6号染色体短臂上的一类基因，编码 MHC蛋白质 。HLA有不同的基因座，编码两大类MHC蛋白。 HLA高度多态性，同一种基因座还有不同的等位基因

Initial efforts to expand cord blood progenitors ex vivo have resulted in expansion of mature rather than immature hematopoietic stem cells. The HLA system is the major histocompatibility barrier in stem cell transplantation, and the degree of HLA matching is predictive of the clinical outcome.

The cell-mediated adaptive immune response is regulated by the major histocompatibility complex (MHC) or human leukocyte antigen (HLA) in humans . HLA molecules are cell surface glycoproteins whose primary function is to present endogenous and exogenous antigens to T lymphocytes for recognition and response . The HLA molecules that present ...

2017年11月30日 · Using LOHHLA, we find that HLA LOH occurs in 40% of non-small-cell lung cancers (NSCLCs) and is associated with a high subclonal neoantigen burden, APOBEC-mediated mutagenesis, upregulation of cytolytic activity, and PD-L1 positivity.

2024年3月5日 · We observed increased T cell proliferation with HLA-DR + neutrophils; further work is needed to detail how they directly activate T cells. Testing antigen presentation to T cells in vitro and analyzing CD4 + /CD8 + T cell responses in vivo could elucidate this.

2023年4月24日 · Human leukocyte antigens (HLA) are genes in major histocompatibility complexes (MHC) that help code for proteins that differentiate between self and non-self. They play a significant role in disease and immune defense. They are beneficial to the immune system but can also have detrimental effects.

2013年7月18日 · The main function of HLA class I gene products (HLA-A, -B, and -C) is to present endogenous peptides to responding CD8+ T Cells while the class II coded molecules HLA-DR, -DP, and –DQ have restricted expression and process exogenous peptides for presentation to CD4+ helper T Cells.

2024年10月29日 · Polymorphic human leukocyte antigen (HLA) class I and killer cell immunoglobulin-like receptors (KIRs) are key regulators of natural killer (NK) cells, which mediate early infection control. How this variation impacts their responses across populations is unclear.