2017年10月30日 · T helper 2 (TH2) cells orchestrate protective type 2 immune responses, such as those that target helminths and facilitate tissue repair, but also contribute to chronic inflammatory...

辅助型T细胞 2 (T helper 2 cell，Th2)是一种能够分泌Th2型 细胞因子 (如 白细胞介素 IL-4、IL-5、IL-10和IL-13等)的 T细胞 亚群，属于 CD4+T细胞。 这些 细胞因子 能够促进Th2细胞增殖，并抑制 Th1细胞 增殖，同时辅助 B细胞 活化，发挥 体液免疫 的作用。 [1] Th2细胞的 前体细胞 为 Th0细胞，是未受 抗原 刺激的初始 CD4+T细胞。 Th0细胞向不同 谱系 (Th1、Th2、Th3等)的分化受到 抗原 的性质、 细胞因子 的种类与 细胞因子 间的平衡的调控。 [1]

In this review, I will focus on the signaling pathways and key molecules that determine the differentiation of naïve CD4 T cells into Th2 cells, and how the expression of Th2 cytokines, especially IL-4 and IL-13, is regulated in Th2 cells.

2017年4月26日 · Th2 cells produce IL-4, IL-5, and IL-13, which are important in humoral immunity and protection from helminth infection and are central to the pathogenesis of many allergic inflammatory diseases. Molecular analysis of Th2 cell differentiation and maintenance of function has led to recent discoveries that have refined our understanding of Th2 ...

Th2 cells are an important part of adaptive immunity. Under normal physiological conditions, Th2 cells play an active role in eliminating parasitic infections and promoting wound healing. On the contrary, abnormal Th2 cell function will lead to many inflammatory diseases, such as AR, AA, AD, ulcerative colitis, chronic periodontitis, etc. [4 ...

Th2 cells produce IL-4, IL-5, and IL-13, which are important in humoral immunity and protection from helminth infection and are central to the pathogenesis of many allergic inflammatory diseases. Molecular analysis of Th2 cell differentiation and maintenance of function has led to recent discoveries that have refined our understanding of Th2 ...

Th2细胞介导针对细胞外寄生虫、细菌、过敏原和毒素的体液或抗体介导的免疫反应的活化和维持。 Th2细胞通过生成各种细胞因子如IL-4、IL-5、IL-6、IL-9、IL-13和IL-17E （IL-25）来介导这些功能。 这些细胞因子负责促进抗体合成、活化嗜酸性粒细胞和抑制多种巨噬细胞功能，从而提供独立于吞噬细胞的保护反应。 这些细胞因子也会抵消Th1反应，使Th2细胞接受IL-4的刺激活化。 在功能上，由于细胞因子受体在多种细胞类型中广泛表达，因此Th2细胞因子对体内的许多细胞 …

Here, we review recent insights into how diverse molecular signals from cellular sources, including dendritic cells, innate lymphoid cells and the epithelium, are integrated by T cells to guide the transcriptional and epigenetic changes necessary for T H 2 cell differentiation.

The type 2 helper Tcell (Th2), characterized by the production of interleukin-4 (IL-4), IL-5 and IL-13, plays a critical role in immune response against helminths invading cutaneous or mucosal sites. It also has a functional role in the pathophysiology of allergic diseases such as asthma and allergic diarrhea.

2000年12月1日 · Cytokines such as interleukin 12 (IL-12) and IL-4 are dominant factors in driving the development of T helper 1 (Th1) and Th2 cells, respectively, through specific signalling pathways.