The cells exhibit ion transport activities consistent with cystic fibrosis and express the product of the CF gene (cystic fibrosis transmembrane regulator, CFTR). CFPAC-1 cells show no effect of cAMP agonists, adenyl cyclase stimulators or phosphodiesterase inhibitors on Cl- flux, but do respond to Ca++ ionophores with increase Cl- efflux.

CFPAC-1细胞是一种源自于26岁白人男性囊性纤维变性（CF）肝转移灶的胰腺管腺癌细胞系。 CFPAC1细胞表现出典型的上皮细胞形态，具有顶端微绒毛极化、紧密连接和间隙连接。 分子层面上，它们表达囊性纤维变性跨膜调节因子（CFTR）以及胰腺管细胞特征性的细胞角蛋白和癌胚抗原。 CFPAC1细胞的倍增时间约为30-32小时，染色体模式数为亚3倍体，其中36%的细胞呈现75个染色体模式。 CFPAC-1细胞展现出与囊性纤维化细胞相似的离子转运活性，对于cAMP激动 …

cfpac-1是胰腺管腺癌细胞系，建自26岁白人男性囊性纤维变性（cf）的肝转移灶。 该细胞系表达囊性纤维变性跨膜调节因子（CFTR）。 形态为上皮样且顶端微绒毛极化。

CFPAC-1 was obtained from a liver metastasis of a 26-year old male with cystic fibrosis. Laparotomy revealed a well-differentiated adenocarcinoma in the head of the pancreas and multiple liver metastases 12.

Specific chromosomal aberrations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas. Higher frequency of DPC4/Smad4 alterations in pancreatic cancer cell lines than in primary pancreatic adenocarcinomas. Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping.

We established a pancreatic adenocarcinoma cell line (CFPAC-1) from a patient with cystic fibrosis (CF) and assessed some of its properties. The cells show epithelial morphology and express cytokeratin and oncofetal antigens characteristic of ...

2025年3月6日 · To screen for genes that behave in a opposite manner in vitro versus in vivo the five transcriptionally distinct human PDAC cell lines (BXPC-3, PANC-1, MIAPACA-2, CFPAC-1, and HPAF-II; Fig. S1a ...

胰腺癌细胞 cfpac-1 皮下移植肿瘤体积生长曲线及小鼠体重变化曲线（ n =6 ）。 将细胞以皮下注射的形式接种到 7周的雄性C-NKG小鼠体内，并在不同的时间点测量成瘤体积。

The cells have the most common form of the CF mutation, deletion of three nucleotides resulting in the absence of phenylalanine at position 508.CFPAC-1 cells have epithelial morphology and polarization with apical microvilli, tight junctions and gap junctions.

cfpac-1细胞是胰腺管腺癌细胞系，建自26岁白人男性囊性纤维变性(cf)的肝转移灶。 CFPAC-1细胞表达囊性纤维变性跨膜调节因子(CFTR)，CFPAC-1细胞形态为上皮细胞样且顶端微绒