2024年4月9日 · We further identified cGAS as an immune tyrosine inhibitory motif (ITIM) containing protein, and demonstrated that cGAS inhibited the progression of HCC and increased the response of HCC to...

2023年3月2日 · Here we show that cGAS is localized to mitochondria and protects hepatocellular carcinoma cells from ferroptosis in vitro and in vivo. cGAS anchors to the outer mitochondrial membrane where it...

2019年11月18日 · Hepatocellular carcinoma (HCC) is the most common primary liver cancer, and the incidence of HCC is increasing. Recently, cancer immunotherapy has emerged as an...

近日，基础医学院韩丽辉教授团队在Cell Death and Differentiation杂志（中科院一区TOP，IF=12.4）发表题为“cGAS suppresses hepatocellular carcinoma independent of its cGAMP synthase...

2025年2月21日 · Our findings indicate that ZMD NPs significantly augment the radiosensitivity of HCC cells and activate the cGAS-STING pathway, thereby catalyzing a potent anti-tumor immune response. In vitro assays reveal that ZMD synergizes with radiotherapy to suppress tumor cell proliferation, migration, and invasion, while also inducing ROS generation ...

cGAS-STING signalling-induced cytokine production exacerbates the sterile inflammatory response associated with NAFLD and liver injury and suppresses the development of HCC. Targeting cGAS-STING signalling has potential therapeutic value for the treatment of liver diseases, especially viral hepatitis and HCC.

Hepatocellular carcinoma (HCC) is the most common primary liver cancer, and the incidence of HCC is increasing. Recently, cancer immunotherapy has emerged as an efficient treatment against some cancers. Here we have used a mouse model of mutagen-induced HCC to explore the therapeutic usefulness of targeting the DNA-activated STING pathway in HCC.

2024年8月27日 · 本研究制备了一种新型基于plga的载双药纳米粒，在原位hcc小鼠模型中逆转免疫抑制性肿瘤微环境，与pd-1抗体联合使用获得了协同抗癌功效，为hcc免疫治疗提供了新思路。

2024年1月17日 · The activated STING pathway in HCC cell, KC, DC, and macrophage can recruit immune cells, inhibit the metabolism and proliferation of HCC cells, induce HCC cell death and autophagy as well as...

Knockout of RNASEH2A in HCC cells greatly reduced cell proliferation and induced the transcription of multiple cGAS-STING (cyclic GMP-AMP synthase-stimulator of interferon genes) targeted type 1 interferon-related genes, including IFIT1, USP18, and CXCL10, which suggests knockout of RNASEH2A may produce immunologic stress and tumor suppressive ...