2018年10月4日 · The capsid protein, which associates with viral DNA, has a pivotal role in enabling cGAS-mediated immune activation. We now find that NONO is an essential sensor of the HIV capsid in the nucleus. NONO protein directly binds capsid with higher affinity for weakly pathogenic HIV-2 than highly pathogenic HIV-1.

2022年10月26日 · We found that genetic reversal of two specific amino acid adaptations in HIV-1 (M) enables activation of TRIM5, cGAS and innate immune responses. We propose a model in which the parental...

揭示了cGAS-STING 通路在识别胞质DNA、诱导产生Ⅰ型干扰素、激发人体天然免疫反应过程中的重要作用。引人关注的是HIV 等逆转录病毒能激动cGAS-STING 通路。此研究成果相继发表在Science、Cell 等各大期刊杂志。

2018年10月4日 · We now find that NONO is an essential sensor of the HIV capsid in the nucleus. NONO protein directly binds capsid with higher affinity for weakly pathogenic HIV-2 than highly pathogenic HIV-1. Upon infection, NONO is essential for cGAS activation by HIV and cGAS association with HIV DNA in the nucleus.

2025年3月18日 · Here, we show that HIV-1 uses chromatin-mediated cGAS inactivation as a mechanism to protect its uvDNA from innate immune activation. Keywords: HIV; cGAS; chromatin; innate immunity. To ensure optimal replication and spread, viruses have evolved countermeasures to evade type 1 IFN-mediated antiviral activity.

2016年10月12日 · In this study, we found that active cGAS and HIV-1 Env expression in donor cells enable transfer of cGAMP to macrophages through HIV-1 Env and receptor/coreceptor-mediated membrane fusion sites, followed by cGAMP binding to STING, thus triggering a TBK-1-dependent type I IFN response in a fashion that bypasses the necessity of functional cGAS ...

The role of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway, which is a major DNA-sensing innate immune signaling pathway, in HIV-1 infection and M. …

2016年10月4日 · Vermeire et al. show that the cytosolic DNA receptor cGAS senses HIV-1 infection and induces type I interferon (IFN-I) production in primary CD4+ T cells. Effective IFN-I induction requires proviral integration and expression of the HIV protein Vpr, while Vpu counteracts cGAS-mediated innate immune activation.

The cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) DNA pathway has emerged as a key innate immune pathway important for antiviral immunity. cGAS binds to double-stranded DNA and catalyzes the production of the second messenger 2′3′-cyclic GMP-AMP, a diffusible cyclic dinucleotide that activates the endoplasmic ...

2013年8月8日 · Here we show that HIV infection activates cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS) to produce cGAMP, which binds to and activates the adaptor protein STING to …