Checkpoint kinase 1, commonly referred to as Chk1, is a serine/threonine-specific protein kinase that, in humans, is encoded by the CHEK1 gene. [5] [6] Chk1 coordinates the DNA damage …

chk1促进cdc25a的蛋白酶体降解，可以降低cdk（细胞周期蛋白依赖性激酶）活性，抑制细胞周期进程，为dna修复争取时间。 CHK1还通过 BRCA1 、 BRCA2 和RAD51的磷酸化促进HR（同 …

DNA damage induces activation of Chk1, which then transduces the checkpoint signal and facilitates cell cycle arrest and DNA damage repair. Significant progress has been made …

2024年12月24日 · CHEK1 (Checkpoint Kinase 1) is a Protein Coding gene. Diseases associated with CHEK1 include Oocyte/Zygote/Embryo Maturation Arrest 21 and Lynch Syndrome 2. …

最新的观点认为CHK1是DNA损伤应答激活的主要标志物，表明CHK1不仅激活了细胞周期检查位点的调节，而且直接影响了DNA修复和细胞凋亡。 因此CHK1在DNA损伤应答机制中的作用能够 …

Originally identified as a mediator of DNA damage response (DDR), checkpoint kinase 1 (Chk1) has a broader role in checkpoint activation in DDR and normal cell cycle regulation. Chk1 …

2024年6月1日 · CHK1 plays a crucial role in cancer biology as it modulates cell cycle checkpoint activation and DNA repair. Furthermore, a number of other cellular functions of CHK1 are also …

2017年11月22日 · Checkpoint kinase 1 (CHK1) is critical for intrinsic cell cycle control and coordination of cell cycle progression in response to DNA damage. Despite its essential...

Chk1 activation via ATR plays a dominant role in response to replication stresses (the replication checkpoint). Chk1 is also required for amplification of DSB-initiated Cdc25A signaling …

2021年1月28日 · A recent study shows that CHK1 is essential for controlling hematopoietic stem and progenitor cell (HSPC) development and expansion; conditional deletion of CHK1 in …