2024年12月24日 · CHRM1 (Cholinergic Receptor Muscarinic 1) is a Protein Coding gene. Diseases associated with CHRM1 include Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1 and Mpox. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

The muscarinic acetylcholine receptor M 1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by the CHRM1 gene. [5] It is localized to 11q13. [5] This receptor is found mediating slow EPSP at the ganglion in the postganglionic nerve, [6] is common in exocrine glands and in the CNS. [7] [8]

Results show that downregulation of cholinergic receptor M1 by histone H3K9me3 impairs calcium signally and contributes to the pathogenesis of Huntington's disease. Decreased muscarinic M1 receptor radioligand binding is found in …

其中，毒蕈碱型乙酰胆碱受体M1（cholinergic receptor muscarinic 1，Chrm1）更是在中枢神经系统中表达最丰富的乙酰胆碱受体亚型之一。 那么，星形胶质细胞上的Chrm1是否在成年海马神经发生和学习记忆中发挥作用，以及是如何发挥作用的呢？

The CHRM1 is predominantly located on pyramidal neurons in the cortex (Zhang et al., 2002; Scarr et al., 2018a) and hippocampus (Scarr et al., 2016a). The CHRM2 is highly expressed in the nucleus basalis and occipital cortex and is present at lower levels in the hippocampus, caudate putamen and other cortical regions (Flynn et al., 1995).

毒蕈碱性胆碱能受体属于更大的 G 蛋白偶联受体家族。 这些受体的功能多样性由乙酰胆碱的结合定义，包括腺苷酸环化酶抑制、磷酸肌醇变性和钾通道介导等细胞反应。 毒蕈碱受体影响乙酰胆碱在中枢和周围神经系统中的许多作用。 毒蕈碱性胆碱能受体 1 参与调节迷走神经诱导的支气管收缩和胃肠道的酸分泌。 编码该受体的基因位于 11q13。 [RefSeq 提供，2008 年 7 月] The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors.

The acetylcholine pathway has been proposed to be important for wakefulness and REM sleep, but genetic evidence has been missing. Using a knockout of acetylcholine receptor genes, Niwa et al. show that Chrm1 and Chrm3 double knockout chronically diminishes REM sleep to an undetectable level and causes a severe short-sleep phenotype.

chrm1，即胆碱能受体毒蕈碱1，别名包括毒蕈碱m1受体、乙酰胆碱受体毒蕈碱1。 它是一种G蛋白偶联受体，由CHRM1基因编码，在中枢神经系统、视网膜和泌尿系统中表达。

Here, we demonstrate activation of the cholinergic muscarinic M1 receptor (CHRM1) in CRPC cells upon acquiring resistance to docetaxel, which is manifested in tumor tissues from PC patients post- vs. pre-docetaxel. Genetic and pharmacological inactivation of CHRM1 restores the efficacy of docetaxel in resistant cells.

2024年12月10日 · Activation of muscarinic acetylcholine receptor 1 promotes invasion of hepatocellular carcinoma by inducing epithelial-mesenchymal transition.