2024年12月24日 · CHSY1 (Chondroitin Sulfate Synthase 1) is a Protein Coding gene. Diseases associated with CHSY1 include Temtamy Preaxial Brachydactyly Syndrome and Brachydactyly. Among its related pathways are Chondroitin sulfate/dermatan …

该基因编码软骨素 N-乙酰半乳糖氨基转移酶家族的成员。 这些酶具有双重葡萄糖醛酸转移酶和半乳糖氨基转移酶活性，并在硫酸软骨素的生物合成中发挥关键作用，硫酸软骨素是一种糖胺聚糖，参与许多生物过程，包括细胞增殖和形态发生。 该基因表达减少可能在结直肠癌中发挥作用，并且该基因的突变是造成四肢轴前短指综合征的原因。 [RefSeq 提供，2011 年 12 月] This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family.

CHSY1 synthesizes chondroitin sulfate, a glycosaminoglycan expressed on the surface of most cells and in extracellular matrices. Glycosaminoglycan chains are covalently linked to a wide range of core protein families and regulate many biologic processes, including cell proliferation and recognition, extracellular matrix deposition, and ...

2023年9月25日 · CHSY1 could promote CD8 + T cell exhaustion through activation of the succinate metabolic and PI3K/AKT/HIF1A pathway, leading to CRC liver metastasis. The combination of CHSY1 knockdown and anti-PD1 contributes to …

2023年9月28日 · 近日，南京医科大学附属第一医院联合江苏省肿瘤医院共同在《Journal of Experimental & Clinical Cancer Research》上发表题为“CHSY1 promotes CD8 T cell exhaustion through activation of succinate metabolism pathway leading to colorectal cancer liver metastasis based on CRISPR/Cas9 screening+”的研究论文。

2020年2月4日 · Using a chondroitin sulfate-specific antibody, we showed that the expression of CHSY1 was significantly associated with CS formation in glioma tissue and cells. In addition, overexpression of...

2025年2月8日 · A novel missense mutation (c.1897 G > A) in the CHSY1 gene in two Temtamy preaxial brachydactyly syndrome patients from a consanguineous Pakistani family. elongation of chondroitin sulfate chains may be tightly regulated by the cooperative expression of chondroitin synthase-1 and chondroitin N-acetylgalactosaminyltransferase-1 in peripheral ...

这个基因编码一种硫酸软骨素N-乙酰半乳糖胺转移酶家族的成员。 这些酶具有葡萄糖醛酸转移酶和半乳糖胺转移酶的双重活性，并在硫酸软骨素的生物合成中起到关键作用，硫酸软骨素是一种参与许多生物过程包括细胞增殖和形态发生的糖胺聚糖。 这个基因的表达减少可能在结直肠癌中发挥作用，而这个基因的突变是导致temtamy前轴短指综合征的原因。 [由RefSeq提供，2011年12月] 该基因暂未发现相关的转录本和蛋白质序列信息。 Hierarchical organization of cortical and …

2025年2月8日 · Chondroitin sulfate (CS) modification of proteins by CHSY1 appears critical for proper regulation of immune cells of the myeloid lineage and for maintaining the integrity of neuronal tissues, since a defect in this gene results in increased inflammation and abnormal phenotypes associated with age-related diseases.

Chondroitin synthase-1 (CHSY1) is an enzyme responsible for the biosynthesis of chondroitin sulfate and has been implicated in the tumorigenesis of several cancer types; however, there is limited information regarding the role of CHSY1 in colorectal cancer.

多因素cox回归分析显示chsy1高表达是胶质瘤病人生存预后不良的独立危险因素（p<0.05），chsy1高表达组中位生存期较低表达组明显缩短（p<0.05）。 MGMT启动子甲基化组胶质母细胞瘤病人中，CHSY1高表达组中位生存期较低表达组明显缩短（P<0.05）。

2010年12月10日 · High-throughput sequencing of all 177 candidate genes detected a truncating frameshift mutation in the gene CHSY1 encoding a chondroitin synthase with a Fringe domain. CHSY1 was secreted from patients' fibroblasts and was required for synthesis of chondroitin sulfate moieties.

chsy1可以通过激活琥珀酸代谢和pi3k/akt/hif1a途径促进cd8+ t细胞耗竭，导致crc肝转移。chsy1 敲低和抗 pd1 的组合有助于协同抵抗 crc 肝转移。青蒿素显着抑制 chsy1 活性，与抗 pd1 联合可以协同治疗 crc 肝转移。

2017年9月10日 · CHSY1 modulated CS expression on cell surface, and its expression regulated malignant phenotypes of HCC cells in vitro and in vivo. Mechanically, CHSY1 activated SHH pathway and enhanced SHH binding to cell surface, whereas CHSY1-induced cell migration, invasion, and metastasis were inhibited by SHH inhibitor.

2023年4月26日 · As chondroitin sulfate synthase 1 (Chsy1) is a crucial enzyme for CS elongation, we hypothesized that in vivo knockdown of Chsy1 at peripheral nerve lesion site may decrease CS and versican accumulation, and result in accelerating neurite regeneration.

2010年12月10日 · CHSY1 encodes a type II transmembrane protein comprising a Fringe motif and a glycosyltransferase domain. CHSY1 was found to be secreted, and functional experiments carried out in patients' cells, human fetal osteoblasts cells, and gliobastoma cells revealed remarkable NOTCH upregulation in the absence of CHSY1 activity.

2022年6月15日 · CHSY1, one of the glycosyltransferases, is involved in the synthesis of chondroitin sulfate. Herein, we found that the expression of Chsy1 was decreased in the knee cartilage of OA rats. In order to investigate the role of CHSY1 in chondrogenesis and OA, we established a Chsy1 stable knockdown cell line in mouse ATDC5 chondrocytes by lentivirus.

2012年3月15日 · Chondroitin sulfate synthase 1 (Chsy1) is one of a family of enzymes that catalyze the extension of chondroitin and dermatan sulfate glycosaminoglycans. Recently, human syndromic brachydactylies have been described to have loss-of …

The role of chondroitin sulfate synthase 1 (CHSY1) in the development and progression of gastric cancer was explored and clarified in this study. The immunohistochemistry analysis of clinical tissue samples as well as data mining of public database showed that CHSY1 was significantly upregulated in gastric cancer and associated with more ...