There are two different MPRs, one of ~300kDa and a smaller, dimeric receptor of ~46kDa. [2][3] The larger receptor is known as the cation-independent mannose 6-phosphate receptor (CI-MPR), while the smaller receptor (CD-MPR) requires divalent cations to …

研究人员报告称，溶酶体靶向嵌合体（LYTACs）是一种双功能分子，有两个结合域（下图），一端携带与细胞表面跨膜受体CI-M6PR（cation-independent mannose-6-phosphate receptor）结合的低聚糖肽（oligoglycopeptide）基团，另一端携带一个与靶蛋白结合的抗体或小分子。

2024年1月1日 · The cation-independent mannose 6-phosphate receptor (CI-M6PR) is a ubiquitous transmembrane receptor whose main intracellular role is to direct enzymes carrying mannose 6-phosphate moieties to lysosomal compartments. Recently, the small membrane-bound portion of this receptor has appeared to be implicated in …

阳离子非依赖性甘露糖 6-磷酸受体 (ci-m6pr) 是一种普遍存在的跨膜受体，其主要细胞内作用是将携带甘露糖 6-磷酸部分的酶引导至溶酶体区室。 最近，该受体的小膜结合部分似乎与许多病理生理过程有关。

2023年11月24日 · lytac的溶酶体靶向受体（ltr）是ci-m6pr，也被称为胰岛素样生长因子-2受体（igf2r），不仅可识别甘露糖-6-磷酸（m6p），也可以与胰岛素样生长因子2（igf2），并以高亲和力结合，进入溶酶体，从而维持igf2的水平。

2024年12月25日 · M6PR (Mannose-6-Phosphate Receptor, Cation Dependent) is a Protein Coding gene. Diseases associated with M6PR include Pompe Disease and Niemann-Pick Disease. Among its related pathways are Sphingolipid metabolism …

2021年3月25日 · First-generation LYTACs used the CI-M6PR that endogenously traffics hydrolases and other cargo to the lysosome (Fig. 1a) 14. LYTACs were composed of a target-binding moiety (for example, an...

CI-M6PR has been proposed as an alternative pathway to induce cell death through the delivery of lymphocyte granule toxins. Several studies indicate that CI-M6PR expressed at the cell membrane binds to granzyme B, a serine protease, secreted by cytotoxic T lymphocytes and natural killer cells, via its M6P moiety and induces endocytosis . In the ...

阳离子-非依赖甘露糖-6-磷酸受体（cation-independent mannose-6-phosphate receptor，CI-M6PR，又称IGF2R）是LTR的典型代表，能够将含有甘露糖-6-磷酸（mannose 6-phosphate，M6P）支链的N糖原修饰的蛋白质转运到溶酶体进行降解【2】。

2020年9月16日 · 不依赖阳离子的甘露-6-磷酸受体（cation-independent mannose-6-phosphate receptor, CI-M6PR，又称为IGF2R），能够将含有甘露糖-6-磷酸（mannose 6-phosphate, M6P）支链的N糖原修饰的蛋白质转运到溶酶体。