
Mannose 6-phosphate receptor - Wikipedia
There are two different MPRs, one of ~300kDa and a smaller, dimeric receptor of ~46kDa. [2][3] The larger receptor is known as the cation-independent mannose 6-phosphate receptor (CI …
Nature:PROTAC之后, LYTAC来了! - 知乎专栏
研究人员报告称,溶酶体靶向嵌合体(LYTACs)是一种双功能分子,有两个结合域(下图),一端携带与细胞表面跨膜受体CI-M6PR(cation-independent mannose-6-phosphate receptor) …
Cation-independent mannose 6-phosphate receptor: From roles …
2024年1月1日 · The cation-independent mannose 6-phosphate receptor (CI-M6PR) is a ubiquitous transmembrane receptor whose main intracellular role is to direct enzymes carrying …
阳离子非依赖性甘露糖 6-磷酸受体:从作用和功能到靶向治 …
阳离子非依赖性甘露糖 6-磷酸受体 (ci-m6pr) 是一种普遍存在的跨膜受体,其主要细胞内作用是将携带甘露糖 6-磷酸部分的酶引导至溶酶体区室。 最近,该受体的小膜结合部分似乎与许多病 …
浙工大葛璟燕课题组JACS:IGF2融合溶酶体靶向嵌合体iLYTAC- X …
2023年11月24日 · lytac的溶酶体靶向受体(ltr)是ci-m6pr,也被称为胰岛素样生长因子-2受体(igf2r),不仅可识别甘露糖-6-磷酸(m6p),也可以与胰岛素样生长因子2(igf2),并以 …
M6PR Gene - GeneCards | MPRD Protein | MPRD Antibody
2024年12月25日 · M6PR (Mannose-6-Phosphate Receptor, Cation Dependent) is a Protein Coding gene. Diseases associated with M6PR include Pompe Disease and Niemann-Pick …
LYTACs that engage the asialoglycoprotein receptor for ... - Nature
2021年3月25日 · First-generation LYTACs used the CI-M6PR that endogenously traffics hydrolases and other cargo to the lysosome (Fig. 1a) 14. LYTACs were composed of a target …
Mannose 6-phosphate receptor targeting and its applications in …
CI-M6PR has been proposed as an alternative pathway to induce cell death through the delivery of lymphocyte granule toxins. Several studies indicate that CI-M6PR expressed at the cell …
Nature:斯坦福Carolyn R. Bertozzi课题组报道新型LYTAC蛋白降解 …
阳离子-非依赖甘露糖-6-磷酸受体(cation-independent mannose-6-phosphate receptor,CI-M6PR,又称IGF2R)是LTR的典型代表,能够将含有甘露糖-6-磷酸(mannose 6 …
Nature |蛋白质组学研究靶向溶酶体的嵌合体可用于降解细胞外蛋白
2020年9月16日 · 不依赖阳离子的甘露-6-磷酸受体(cation-independent mannose-6-phosphate receptor, CI-M6PR,又称为IGF2R),能够将含有甘露糖-6-磷酸(mannose 6-phosphate, …