2023年10月1日 · In this study, in addition to the CiOA model, we evaluated the general relevance of GM-CSF and CCL17 in other commonly used mouse OA models, namely, the destabilization of the medial meniscus (DMM)- and monosodium iodoacetate (MIA)-induced OA, and found that both GM-CSF and CCL17 are again required for the development of pain and optimal disease.

Here, we uncovered elevation of ALPK1 in degraded cartilage of destabilized medial meniscus (DMM) and collagenase-induced osteoarthritis (CIOA), two different mouse OA models induced by mechanical stress or synovitis.

巨噬细胞表型与胶原酶诱导的骨关节炎 (CIOA) 中的骨关节炎过程和内侧半月板 (DMM) 小鼠模型的不稳定有关 Osteoarthritis and Cartilage ( IF 7.2) Pub Date : 2017-04-01, DOI: 10.1016/j.joca.2017.02.454

2018年10月31日 · 南方医科大学白晓春与蔡道章教授研究团队在骨关节炎研究领域取得重要进展，研究成果分别以“Tyrosine Kinase Fyn Promotes Osteoarthritis by Activating the β-catenin Pathway（酪氨酸激酶Fyn通过激活b-catenin通路促进骨关节炎发展）”和“Synovial Macrophage M1 Polarization Exacerbates Experimental Osteoarthritis Partially through R-spondin-2（M1型极化的滑膜巨噬细胞通过分泌R-spondin-2促进骨关节炎进展）”为题，于2018年3月19日和7 …

有研究者筛选总结转基因动物模型文献，发现敲除小鼠 Col11a1 、 Col2a1 基因，或 Del1、Ⅱ 型、Ⅸ型胶原基因突变，或软骨基质基因缺陷，均可诱发OA。

DMM （Destabilization of the Medial Meniscus, DMM Model）手术造模骨关节炎模型是一种通过外科手术方法诱导的骨关节炎（Osteoarthritis, OA）动物模型，用于模拟人类骨关节炎的发病过程。

2022年6月1日 · The DMM surgical model involves sectioning the medial meniscotibial ligament in the knee joint that anchors the medial meniscus to the tibial plateau [Fig. 1 (B)] 60, 61, 62. The DMM induced instability leads to cartilage degradation from 2 weeks post-surgery and progressively expands to subchondral bone sclerosis and osteophyte formation 63 , 64 .

2020年5月31日 · Here, we use two mouse models of experiment OA – collagenase-induced osteoarthritis (CIOA) and destabilization of the medial meniscus (DMM) – to quantify the immune cell infiltration into the knee joint during the early stages of disease.

2022年8月4日 · Here, we uncovered elevation of ALPK1 in degraded cartilage of destabilized medial meniscus (DMM) and collagenase-induced osteoarthritis (CIOA), two different mouse OA models induced by mechanical stress or synovitis.

利用胶原酶注射的方法建立cioa大鼠模型，通过酶联免疫法检测血清及关节液中cfdna、il-6、il-1β、tnf-α的含量。 结果表明，血清及关节液中cfDNA、IL-6、IL-1β、TNF-α的含量在MSN-PEI处理后，明显减少。