2024年12月24日 · CNOT1 (CCR4-NOT Transcription Complex Subunit 1) is a Protein Coding gene. Diseases associated with CNOT1 include Vissers-Bodmer Syndrome and …

CCR4-NOT transcription complex subunit 1 is a protein that in humans is encoded by the CNOT1 gene. [5] [6] It is a part of the CCR4-Not complex, which deadenylates mRNAs. [7] CNOT1 …

2020年7月2日 · CNOT1 is a member of the CCR4-NOT complex, which is a master regulator, orchestrating gene expression, RNA deadenylation, and protein ubiquitination. We report on …

In this study, we addressed the function of the CNOT1 subunit by depleting its expression in HeLa cells. Flow cytometric analysis revealed that the sub G 1 fraction was increased in CNOT1 …

2025年2月9日 · the CNOT1-LMNA-Hedgehog signaling pathway axis exerts an oncogenic role in osteosarcoma progression, which could be a potential target for gene therapy. we …

CCR4-NOT is the main enzyme responsible for mRNA deadenylation, which shortens the poly (A) tail in mRNA, thus leading to mRNA degradation. CNOT1 is expressed in early embryonic …

2020年12月2日 · Here we show that the CCR4-NOT complex limits expression of specific genes through deadenylation of mRNA poly (A) tails, enabling positive selection. Specifically, the …

2024年1月15日 · Contributes to poly (A)-specific ribonuclease activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of …

Ubiquitous expression in testis (RPKM 56.3), esophagus (RPKM 28.6) and 25 other tissues. 启用犰狳重复域绑定活动；分子衔接活性；和核受体结合活性。 有助于聚 (A) 特异性核糖核酸酶活 …

2023年1月31日 · The largest subunit, CNOT1 (Not1 in yeast), serves as the backbone of the CCR4-NOT complex and interacts with most other core subunits to form distinct structural and …