2024年12月24日 · CNTN1 (Contactin 1) is a Protein Coding gene. Diseases associated with CNTN1 include Congenital Myopathy 12 and Congenital Lethal Myopathy, Compton-North Type. Among its related pathways are NOTCH2 Activation and Transmission of Signal to the Nucleus and Nervous system development.

Contactin 1 (CNTN1) is a protein which in humans is encoded by the CNTN1 gene. [5] [6]

Cntn1, a subset of the neural cell adhesion protein and immunoglobulin supergene family, participates in cell contact formation and axonal growth control and plays a role in degenerative and inflammatory disorders. However, neuronal substrates that mediate Cntn1 action on depression-like phenotypes and involved mechanisms are unclear.

Accumulating evidence from recent years suggest Contactin 1 (CNTN1)’s possession of multiple oncogenic activities in a variety of cancer types. CNTN1 is a cell adhesion molecule that is dysregulated in many human carcinomas and plays important roles in …

结果发现，HDM与CNTN1联合引发的BMDCs处理的小鼠肺炎性细胞因子水平升高，支气管周炎症增强，粘液产生增加。这些数据证实CNTN1引发的DCs促进哮喘的发展。 作者进一步发现在CNTN1暴露后，BMDCs中在mRNA和蛋白水平上Notch2的表达增加，Co-IP证实CNTN1和Notch2存在相互作用。

2025年1月10日 · CNTN1基因的主要功能是编码一种称为Contactin 1的蛋白质，这种蛋白质在神经系统中扮演着关键角色。 Contactin 1 主要参与 细胞间的粘附 和 信号传递 ，这对于神经元的正常功能和神经网络的形成至关重要。

cntn1是一种神经元膜糖蛋白，如果过表达，则会在不同的癌细胞系，癌症组织和转基因小鼠中发现。 它与淋巴管浸润，转移，晚期TNM分期和较短的总生存时间呈正相关。

Mutations in CNTN1, a neural adhesion molecule and neuromuscular junction protein, cause a familial form of lethal congenital myopathy. The repulsive properties of contactin may be a key factor in glioma disaggregation, and may contribute to the diffuse infiltration pattern characteristic of glioma cells in human brain.

2021年1月3日 · CNTN1是少突胶质细胞表面Notch受体的功能性配体，通过CNTN1/Notch/Deltex1信号通路促进少突胶质细胞前体细胞分化、促进少突胶质细胞成熟，并通过诱导少突胶质细胞表达髓鞘相关蛋白 (myelin-associated glycoprotein，MAG) 参与髓鞘形成[20]；此外，受体型蛋白酪氨酸磷酸酶β ...

接触蛋白-1(cntn1)属于神经细胞黏附分子之一,是免疫球蛋白超家族的一个亚组,其通过糖基磷脂酰肌醇锚定的神经元膜蛋白锚定在细胞表面,参与轴突导向、突触形成以及多种神经系统生长、发育和疾病的发生过程.此外,cntn1可通过多种机制促进炎症反应以及小胶质 ...