Specific Pyruvate Kinase M2 Inhibitor, Compound 3K, Induces Autophagic ...
Pyruvate kinase M2 (PKM2) plays a pivotal role in regulating cancer cell survival. However, its therapeutic role remains unclear. Here, we investigated the anticancer effects of compound …
Specific Pyruvate Kinase M2 Inhibitor, Compound 3K, Induces
2021年5月5日 · Our findings suggest that the inhibition of PKM2 by compound 3K affected the Warburg effect and induced autophagic cell death. Therefore, use of specific PKM2 inhibitors …
PKM2-IN-1 | PKM2抑制剂 | MCE - MCE-生物活性分子大师
PKM2-IN-1（Compound 3k）是一种丙酮酸激酶 M2 (PKM2) 抑制剂，IC 50 为 2.95 μM。结果表明，大多数测试化合物表现出一定程度的 PKM2 抑制作用，并且某些化合物（例如 PKM2-IN …
Cardioprotective potential of compound 3K, a selective PKM2 …
2024年4月1日 · Compound 3K, a specific PKM2 inhibitor treatment, significantly reduced PKM2 expression, normalized ratio PKM2/PKM1, and normalized PKM1 expression in MI rats. …
PKM2 inhibitor(compound 3k) | PKM2抑制剂(化合物3k) | PKM
PKM2 inhibitor (Compound 3K, PKM2-IN-1)是 PKM2 抑制剂，IC50为2.95 μM。 对PKM1的IC50值比对PKM2的IC50值高4-5倍。 在一系列高表达PKM2的癌细胞系（包括HCT116、Hela …
化合物 3K 通过抑制丙酮酸激酶 M2 (PKM2) 途径减轻异丙肾上腺素 …
用化合物3K治疗导致PKM2蛋白表达下调和PKM1蛋白表达上调。化合物 3K 通过改善心电图、心脏功能、肥大标志物、炎症和纤维化显示出心脏保护作用。此外，它还降低了 PKM2 相关剪接 …
特异性丙酮酸激酶 M2 抑制剂化合物 3K 通过破坏卵巢癌细胞中的 …
Our findings suggest that the inhibition of PKM2 by compound 3K affected the Warburg effect and induced autophagic cell death. Therefore, use of specific PKM2 inhibitors to block the …
这所院校又添新作：化合物3 K通过抑制丙酮酸激酶M2（PKM2） …
2024年6月13日 · 本研究旨在探讨一种名为Compound 3K的PKM2选择性抑制剂在异丙肾上腺素（ISO）诱导的心脏肥大模型中的心脏保护潜力。 研究采用雄性W 智能科学信息平台
Down-regulation of NOTCH1 and PKM2 can inhibit the growth …
This study was designed to investigate the association between PKM2 and the Notch signaling pathway, and determine whether simultaneous suppression of PKM2 and NOTCH1 with …
Compound 3K attenuates isoproterenol-induced cardiac …
2024年8月15日 · Compound 3K showed cardioprotective effects by improving ECG, cardiac functions, hypertrophy markers, inflammation, and fibrosis. Further, it also reduced cardiac …