Catechol-O-methyltransferase is involved in the inactivation of the catecholamine neurotransmitters (dopamine, epinephrine, and norepinephrine).The enzyme introduces a methyl group to the catecholamine, which is donated by S-adenosyl methionine (SAM). Any compound having a catechol structure, like catecholestrogens and catechol-containing flavonoids, are …

2023年11月30日 · 3. It's also key to eat foods that remove excess catachol estrogens from the body and avoid foods and bath products that mimic estrogen.. Excess estrogen slows COMT and COMT is largely responsible ...

Get tested for COMT gene mutation here. What is the COMT Gene and Enzyme? The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. This enzyme is involved in the breakdown of certain neurotransmitters, such as dopamine, epinephrine, and norepinephrine.

Between 20 and 30 percent of Caucasians of European descent have a COMT mutation. This means that the gene that produces an enzyme to break down certain substances and toxins doesn’t work the way it should, causing a range of health, hormone, and stress-related issues.

Other disorders. Variations in the COMT gene also may be associated with mental illness in people without 22q11.2 deletion syndrome. Researchers have looked extensively at the potential connection between changes in the COMT gene and the risk of developing schizophrenia. Most studies have focused on the effects of a particular common variation (polymorphism) in …

2024年5月7日 · There’s been growing interest in the COMT gene recently, given that it can affect things like anxiety, mental fatigue, obsessiveness, and breast cancer risk.

2023年9月28日 · Introduction to COMT Mutations. The realm of genetics is a fascinating field, teeming with potential discoveries that could significantly improve our understanding of human health and disease. One such area of interest is the Catechol-O-methyltransferase (COMT) gene. This gene plays a crucial role in the regulation of several critical bodily functions, and …

2023年2月23日 · What does the COMT enzyme do? COMT (catechol-O-methyltransferase) is a central enzyme that breaks down catecholamines including dopamine, norepinephrine, and epinephrine. COMT plays a vital role in regulating dopamine signaling in the prefrontal cortex where dopamine transporters are relatively sparse.1 Dopamine levels here are critical for …

2024年4月3日 · The COMT gene, also known as catechol-O-methyltransferase, plays a crucial role in the regulation of neurotransmitters in the brain. This gene is involved in the breakdown of catecholamines, including dopamine and norepinephrine, which are essential for …

The interaction of genetic and environmental factors may affect the course and development of psychotic disorders. We examined whether the effects of childhood trauma on cognition and symptoms in schizophrenia were moderated by the Catechol-O-methyltransferase (COMT) Val(158)Met polymorphism, a common genetic variant known to affect cognition and prefrontal …